{"id":"W1978128526","doi":"10.1016/s0168-3659(99)00285-0","title":"Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan","year":2000,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":293,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Mucoadhesion; Chemistry; Chitosan; Bioavailability; Gelatin; Excipient; Dosage form; Hyaluronic acid; Nasal administration; Chromatography; Controlled release; Drug delivery; Drug carrier; Pharmacology; Nuclear chemistry; Biochemistry; Organic chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001382689,0.000131225,0.0005506026,0.00008564199,0.00006168724,0.00000616346,0.00009360172,0.0001131777,0.00003645189],"category_scores_gemma":[0.0003011147,0.00008508423,0.00008508877,0.0001011457,0.0002466661,0.0001814827,0.00002595639,0.0003015535,1.715207e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002722832,"about_ca_system_score_gemma":0.0001863282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002416944,"about_ca_topic_score_gemma":0.00001755318,"domain_scores_codex":[0.9977374,0.0008352585,0.0008929294,0.0001228445,0.0002896274,0.0001219413],"domain_scores_gemma":[0.9983886,0.0002484758,0.0009298165,0.000112459,0.0002439803,0.00007667977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01943806,0.0003181038,0.002196117,0.0001282624,0.0001321058,0.000001831811,0.00143866,0.008133252,0.9451708,0.0000100322,0.00002503085,0.02300773],"study_design_scores_gemma":[0.04184297,0.000427954,0.005233347,0.000297351,0.0007159411,0.00009326693,0.0005422576,0.111449,0.8389267,0.0001181623,0.0002233958,0.0001296504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791778,0.01954944,0.00001081497,0.0002227302,0.0001216865,0.0007931908,0.00001303767,0.00000221325,0.0001091364],"genre_scores_gemma":[0.9984515,0.001251459,0.0001024785,0.00005136272,0.00004531122,0.00001047681,6.26349e-7,0.000008785571,0.00007802022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1062441,"threshold_uncertainty_score":0.3469634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05826768971070611,"score_gpt":0.373531267738365,"score_spread":0.3152635780276589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}