{"id":"W1978136788","doi":"10.1021/bi026731o","title":"Hepatocyte ApoB-Containing Lipoprotein Secretion Is Decreased by the Grapefruit Flavonoid, Naringenin, via Inhibition of MTP-Mediated Microsomal Triglyceride Accumulation","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Center for Research Resources; Heart and Stroke Foundation of Canada","keywords":"Naringenin; Secretion; Chemistry; Apolipoprotein B; Microsomal triglyceride transfer protein; Microsome; Biochemistry; Lipoprotein; Flavonoid; Cholesterol; Enzyme; Very low-density lipoprotein; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169431,0.0003628914,0.0003843317,0.0001336258,0.0001030904,0.0002522416,0.0001355331,0.0001907588,0.0004748373],"category_scores_gemma":[0.00009769435,0.0001544137,0.0002556257,0.0001179125,0.0001637658,0.0001347407,0.000113751,0.0003418907,0.0002755241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004208823,"about_ca_system_score_gemma":0.0002172888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001421268,"about_ca_topic_score_gemma":0.001614366,"domain_scores_codex":[0.9999167,0.00001542422,0.000009706039,0.00002153091,0.000022688,0.00001406248],"domain_scores_gemma":[0.9999412,0.000009951857,0.00001732574,0.000007725969,0.000008377659,0.00001544629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001320228,0.000009895813,0.00005506781,0.00001303614,0.000002765923,0.0000117087,0.000004476369,0.00002446732,0.9993553,0.00001309199,0.00001014268,0.0003681158],"study_design_scores_gemma":[0.00003274246,0.000323264,0.00542802,0.000002147093,0.00001817988,0.00009138259,0.00001281025,0.001182949,0.9918581,0.00001875692,0.001027261,0.000004272541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971645,0.0009297564,0.001042089,0.00006553143,0.00001273183,0.00001335119,0.0001550622,0.00006785785,0.0005490674],"genre_scores_gemma":[0.9951103,0.0007479647,0.001676701,0.00002808784,0.000009246508,0.0000248506,0.0003259149,0.00002007901,0.002056726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421268,"threshold_uncertainty_score":0.003053725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646901282081732,"score_gpt":0.2554287815131073,"score_spread":0.23895976869229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}