{"id":"W1978136788","doi":"10.1021/bi026731o","title":"Hepatocyte ApoB-Containing Lipoprotein Secretion Is Decreased by the Grapefruit Flavonoid, Naringenin, via Inhibition of MTP-Mediated Microsomal Triglyceride Accumulation","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Center for Research Resources; Heart and Stroke Foundation of Canada","keywords":"Naringenin; Secretion; Chemistry; Apolipoprotein B; Microsomal triglyceride transfer protein; Microsome; Biochemistry; Lipoprotein; Flavonoid; Cholesterol; Enzyme; Very low-density lipoprotein; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002875952,0.0002425382,0.0003245739,0.00005519461,0.0001182752,0.00002645083,0.00008293035,0.0002628194,0.000145925],"category_scores_gemma":[0.0002513818,0.0001989611,0.0001682742,0.0002736695,0.0001164112,0.00007703244,0.00002667463,0.0002516547,0.00001436163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008306618,"about_ca_system_score_gemma":0.0001300599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002173717,"about_ca_topic_score_gemma":0.000004605622,"domain_scores_codex":[0.9984949,0.00006194809,0.000475769,0.0003618924,0.0003270408,0.0002784942],"domain_scores_gemma":[0.9989364,0.00005439949,0.0002820472,0.0004100344,0.0001532774,0.0001638691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005724632,0.0001025968,0.002270419,0.0001156376,0.00005061229,0.000003668826,0.0002331623,8.380691e-7,0.9931259,0.000005206854,0.0004705591,0.003048904],"study_design_scores_gemma":[0.003431673,0.00008418802,0.002521789,0.0001375529,0.0001255197,0.00005137499,0.0001319276,0.000408532,0.9897154,0.0000397583,0.003162672,0.0001896262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969457,0.001079715,0.0005156472,0.0002573759,0.0001057292,0.0004861981,0.00004834206,0.00006480816,0.0004965128],"genre_scores_gemma":[0.9978955,0.00003938227,0.0002503963,0.0005105598,0.0002440985,0.00005985356,0.0005456567,0.00003309101,0.000421407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003410547,"threshold_uncertainty_score":0.81134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646901282081732,"score_gpt":0.2554287815131073,"score_spread":0.23895976869229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}