{"id":"W1978151577","doi":"10.1371/journal.pone.0053036","title":"Depletion of Nuclear Poly(A) Binding Protein PABPN1 Produces a Compensatory Response by Cytoplasmic PABP4 and PABP5 in Cultured Human Cells","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Poly(A)-binding protein; Cell biology; Biology; Cell nucleus; Polyadenylation; Cytoplasm; Messenger RNA; HEK 293 cells; Nuclear export signal; RNA interference; Molecular biology; RNA-binding protein; Cell culture; RNA; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001298172,0.00023412,0.0002511808,0.0001757975,0.0001841061,0.0002732865,0.0001633723,0.0002336189,0.001820498],"category_scores_gemma":[0.0001438232,0.0001310618,0.0002629047,0.0002105881,0.0001663846,0.00009532133,0.0001507897,0.0004751343,0.0006950072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003314663,"about_ca_system_score_gemma":0.000273633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00174445,"about_ca_topic_score_gemma":0.001270597,"domain_scores_codex":[0.999842,0.00002037934,0.00001842747,0.00005181515,0.00004375307,0.00002355561],"domain_scores_gemma":[0.999905,0.00002576561,0.00001982612,0.00001811802,0.00001379834,0.00001747158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001900617,0.00003334076,0.0006331378,0.00006561932,0.0000124387,0.000168202,0.00003244605,0.0001188595,0.996167,0.00007734847,0.000238638,0.002262933],"study_design_scores_gemma":[0.00001424307,0.0002158304,0.005023472,0.000008019744,0.00002657554,0.000423055,0.00003072066,0.001012678,0.9882823,0.000039854,0.004917442,0.000005749321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978096,0.008080246,0.006871143,0.0002484048,0.0001156409,0.00005688287,0.002014319,0.0003550161,0.004162291],"genre_scores_gemma":[0.9852878,0.002303502,0.003681516,0.0001352571,0.00001783,0.0001047494,0.002734201,0.00004013262,0.005694994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001820498,"threshold_uncertainty_score":0.006090224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02205570898518403,"score_gpt":0.2439574612829292,"score_spread":0.2219017522977451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}