{"id":"W1978188503","doi":"10.1177/0091270011399577","title":"Opioid Receptor Modulation of Hedonic Taste Preference and Food Intake: A Single‐Dose Safety, Pharmacokinetic, and Pharmacodynamic Investigation With GSK1521498, a Novel μ‐Opioid Receptor Inverse Agonist","year":2011,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Overeating; Inverse agonist; Pharmacokinetics; Pharmacodynamics; Pharmacology; Endogenous opioid; Opioid; Agonist; Taste; Opioid receptor; Medicine; Receptor; Endocrinology; Chemistry; Internal medicine; Obesity; Food science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005482375,0.0006825546,0.001073598,0.0003076876,0.0002331652,0.0004212903,0.0004769583,0.0006864514,0.001423782],"category_scores_gemma":[0.0007624523,0.0005178124,0.0006804827,0.0002453152,0.0004619985,0.0005164743,0.0001643476,0.001250402,0.0003369452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000358832,"about_ca_system_score_gemma":0.0005396694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004435422,"about_ca_topic_score_gemma":0.001503345,"domain_scores_codex":[0.9997144,0.0001096711,0.0000228062,0.00004520415,0.00006296718,0.00004495069],"domain_scores_gemma":[0.9996607,0.00008062352,0.0001076914,0.00005042126,0.00003074639,0.00006971624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0692881,0.009778501,0.004036181,0.000434739,0.000427802,0.000365161,0.0002126248,0.0007276282,0.8466398,0.0002463804,0.0006343675,0.06720865],"study_design_scores_gemma":[0.0245868,0.4283653,0.06585497,0.00004612105,0.0009799236,0.002873641,0.0001710162,0.005158726,0.467341,0.0002368325,0.004284841,0.0001008294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974081,0.0008522504,0.0007243758,0.00009603648,0.0000232996,0.0001886995,0.0001804635,0.00004733237,0.0004793744],"genre_scores_gemma":[0.9964772,0.0008539461,0.001289535,0.00007995403,0.00002511989,0.0001764485,0.0002716557,0.00001290631,0.0008132194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001423782,"threshold_uncertainty_score":0.004763007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1585381157846783,"score_gpt":0.3344828411170219,"score_spread":0.1759447253323436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}