{"id":"W1978188503","doi":"10.1177/0091270011399577","title":"Opioid Receptor Modulation of Hedonic Taste Preference and Food Intake: A Single‐Dose Safety, Pharmacokinetic, and Pharmacodynamic Investigation With GSK1521498, a Novel μ‐Opioid Receptor Inverse Agonist","year":2011,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Overeating; Inverse agonist; Pharmacokinetics; Pharmacodynamics; Pharmacology; Endogenous opioid; Opioid; Agonist; Taste; Opioid receptor; Medicine; Receptor; Endocrinology; Chemistry; Internal medicine; Obesity; Food science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001000284,0.0002818929,0.0006570571,0.00012988,0.0001543452,0.00001720192,0.000458516,0.0001155128,0.0002230129],"category_scores_gemma":[0.0003516031,0.0001889775,0.0001042495,0.000277142,0.001559172,0.0003880798,0.0002409459,0.0008690006,0.000008790163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003004451,"about_ca_system_score_gemma":0.0001867173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001224794,"about_ca_topic_score_gemma":0.000007785332,"domain_scores_codex":[0.9965711,0.00102369,0.001406321,0.0003880204,0.000279535,0.0003313081],"domain_scores_gemma":[0.9964191,0.001244932,0.001657593,0.0001592073,0.0002142331,0.0003048932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005973464,0.0004492833,0.0008105511,0.00006889196,0.00008508618,0.000005231329,0.0006077091,0.0001009411,0.9842398,0.0001362705,0.0004295806,0.007093199],"study_design_scores_gemma":[0.0192525,0.02198642,0.04412676,0.000267696,0.0009474512,0.0005209349,0.0002198622,0.008466133,0.893086,0.001937381,0.008486076,0.0007028511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975913,0.0001263281,0.0001363443,0.0004563519,0.0009667207,0.0004593152,0.00004330821,0.00002023009,0.0002001038],"genre_scores_gemma":[0.9927807,0.003530281,0.0009523699,0.002223769,0.0004274859,0.000005863401,0.000002348722,0.00003453824,0.00004259056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09115385,"threshold_uncertainty_score":0.7706277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1585381157846783,"score_gpt":0.3344828411170219,"score_spread":0.1759447253323436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}