{"id":"W1978188597","doi":"10.1007/s00253-012-4654-3","title":"Heterologous expression of CYP102A5 variant from Bacillus cereus CYPPB-1: Validation of model for predicting drug metabolism of human P450 probe substrates","year":2013,"lang":"en","type":"article","venue":"Applied Microbiology and Biotechnology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Windsor","funders":"Council of Scientific and Industrial Research, India","keywords":"Bacillus cereus; In silico; Biochemistry; Chemistry; Drug metabolism; Docking (animal); Homology modeling; Biology; Metabolism; Enzyme; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000446757,0.0003231936,0.0008342033,0.0002412713,0.0001536473,0.000004487362,0.0004372865,0.001255796,0.0001232364],"category_scores_gemma":[0.00004302978,0.0002802468,0.0001188468,0.0001480081,0.0009819889,0.00005543312,0.0002680198,0.0005436925,0.000003325155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001040063,"about_ca_system_score_gemma":0.00004869211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000889662,"about_ca_topic_score_gemma":0.00001392507,"domain_scores_codex":[0.9978837,0.0001700765,0.0009095951,0.0005315653,0.00004981937,0.0004552893],"domain_scores_gemma":[0.998332,0.0003476888,0.0007529684,0.0003161929,0.000169796,0.00008138356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002779191,0.0003640366,0.0004770816,0.0001085806,0.0002336731,7.846263e-7,0.0006380851,0.0003716951,0.9899176,0.003551372,0.0001691591,0.003889965],"study_design_scores_gemma":[0.002470883,0.0001217003,0.0003552638,0.00001548443,0.0002929811,0.00001226937,0.0001782544,0.002406409,0.9820189,0.01128178,0.0006205742,0.0002254888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930355,0.001943332,0.002104035,0.0002475698,0.0002500087,0.001140969,0.001124965,0.00006578696,0.00008785827],"genre_scores_gemma":[0.9935046,0.0005103098,0.005166841,0.0001696184,0.00006286062,0.0001566513,0.0003720262,0.00002682333,0.0000302001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00789874,"threshold_uncertainty_score":0.999965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04365088839581922,"score_gpt":0.3228833034746361,"score_spread":0.2792324150788169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}