{"id":"W1978203600","doi":"10.1371/journal.pone.0008625","title":"Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; University of Oxford; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; European Synchrotron Radiation Facility; Wellcome Trust","keywords":"Hsp70; Gene isoform; Biology; Heat shock protein; Protein domain; Chaperone (clinical); Cyclic nucleotide-binding domain; Protein structure; ATPase; Cell biology; Biochemistry; Peptide sequence; Gene; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003261005,0.0007234094,0.0007332186,0.0002757059,0.0008439212,0.0007049986,0.0009054811,0.0007600511,0.006245465],"category_scores_gemma":[0.0005747881,0.0003822114,0.0003700235,0.0007213957,0.0001919592,0.0003782764,0.0004401455,0.00153076,0.001162295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001327639,"about_ca_system_score_gemma":0.0008793934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005378633,"about_ca_topic_score_gemma":0.008968914,"domain_scores_codex":[0.9997484,0.00002077985,0.00001192286,0.0000431132,0.0001441022,0.00003167843],"domain_scores_gemma":[0.9998271,0.00003458768,0.00002929403,0.00000889314,0.00006503398,0.00003512063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003858824,0.002410477,0.01971648,0.004731665,0.0009959661,0.002072036,0.002431274,0.02080636,0.6089152,0.01254137,0.2134874,0.1080329],"study_design_scores_gemma":[0.003165429,0.0008645171,0.1308671,0.0008239892,0.0008619206,0.003696207,0.001856311,0.09927636,0.3827496,0.004031557,0.3714921,0.0003149344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9116027,0.01685715,0.006382775,0.002606214,0.0005779561,0.0001883797,0.03642491,0.001937854,0.02342217],"genre_scores_gemma":[0.8215505,0.009262186,0.02809329,0.0006240386,0.00009317227,0.0004733602,0.1151291,0.0007719242,0.02400242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006245465,"threshold_uncertainty_score":0.02089316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02528059992445263,"score_gpt":0.2595628704113393,"score_spread":0.2342822704868867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}