{"id":"W1978206894","doi":"10.1007/s11010-012-1262-6","title":"Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators","year":2012,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; China Scholarship Council; Heart and Stroke Foundation of Canada","keywords":"Gene knockdown; Small hairpin RNA; Cell cycle; Cell growth; Cell cycle checkpoint; Biology; Cell biology; Cell; Downregulation and upregulation; G1 phase; Cell culture; Molecular biology; RNA interference; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000267467,0.0002318827,0.0001908053,0.00003819523,0.0001058779,0.00003822066,0.0001207237,0.0002675021,0.000008501775],"category_scores_gemma":[0.00006262621,0.0002319015,0.00006571601,0.00009717612,0.0001259737,0.00001260176,0.0001728044,0.0001613819,0.000001419037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000114337,"about_ca_system_score_gemma":0.00005121591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002457605,"about_ca_topic_score_gemma":5.892156e-7,"domain_scores_codex":[0.9985756,0.00006253731,0.0002665751,0.0003804135,0.0002439085,0.0004709991],"domain_scores_gemma":[0.9991823,0.00001151489,0.0001227852,0.0002831394,0.00006471538,0.0003354782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002523856,0.0001014408,0.005893358,0.0002034376,0.00002167295,0.000002314375,0.00004717939,0.000005799708,0.9929276,0.000006390898,0.0002257842,0.0005397518],"study_design_scores_gemma":[0.0005396552,0.00008675732,0.00006850511,0.00002137567,0.00002266557,0.000006754071,0.0001774535,0.0001073878,0.9985299,0.00001377191,0.0001760599,0.000249715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878891,0.01001347,0.0009311853,0.00004598161,0.00004393595,0.0001676622,0.00002301907,0.000009759027,0.0008758721],"genre_scores_gemma":[0.9987132,0.0000949271,0.0003275627,0.00006840624,0.0001337464,0.00001833574,0.0002521953,0.00003262328,0.0003589842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0108241,"threshold_uncertainty_score":0.945667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00387631932186303,"score_gpt":0.2128158354472861,"score_spread":0.2089395161254231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}