{"id":"W1978216180","doi":"10.1371/journal.pone.0010575","title":"Hepatitis C Virus Controls Interferon Production through PKR Activation","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Centre National de la Recherche Scientifique","keywords":"Protein kinase R; Internal ribosome entry site; EIF-2 kinase; Interferon; Biology; Virology; Hepatitis C virus; Eukaryotic initiation factor; Gene silencing; NS3; Initiation factor; NS2-3 protease; RNA silencing; RNA; Virus; Protein kinase A; Kinase; Translation (biology); RNA interference; Messenger RNA; Cell biology; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000132208,0.0001395259,0.0002350213,0.00006649223,0.0001402449,0.00002007188,0.0001401101,0.0002128862,0.0018177],"category_scores_gemma":[0.0004103974,0.0001273375,0.00005197642,0.00006933451,0.000138915,0.0002615928,0.00004452093,0.0004945087,0.001461761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003162274,"about_ca_system_score_gemma":0.00002975658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005270909,"about_ca_topic_score_gemma":0.0002726505,"domain_scores_codex":[0.9991186,0.0001307599,0.00022509,0.0002442883,0.00004288661,0.0002384357],"domain_scores_gemma":[0.999376,0.00007908195,0.0001010921,0.0003080591,0.0001254107,0.00001033425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008674397,0.0008463389,0.0009102857,0.00001629296,0.0002748351,4.755851e-7,0.0004162095,1.022844e-7,0.9933445,0.0006046789,0.001354223,0.001364565],"study_design_scores_gemma":[0.0005877928,0.0004368147,0.004668924,0.0000789305,0.00005260024,0.00001105965,0.00003826623,0.000002424117,0.9859346,0.0001451105,0.007902713,0.000140825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951008,0.0001931274,0.0001140339,0.001035536,0.0008613876,0.0003411864,0.00001152919,0.000131711,0.00221068],"genre_scores_gemma":[0.9894977,0.0002024337,0.0002155088,0.0002549,0.0001243215,0.00006334915,0.00007329904,0.00001934303,0.009549122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007410014,"threshold_uncertainty_score":0.9993157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02915202599061934,"score_gpt":0.2371057419278434,"score_spread":0.2079537159372241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}