{"id":"W1978216180","doi":"10.1371/journal.pone.0010575","title":"Hepatitis C Virus Controls Interferon Production through PKR Activation","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Centre National de la Recherche Scientifique","keywords":"Protein kinase R; Internal ribosome entry site; EIF-2 kinase; Interferon; Biology; Virology; Hepatitis C virus; Eukaryotic initiation factor; Gene silencing; NS3; Initiation factor; NS2-3 protease; RNA silencing; RNA; Virus; Protein kinase A; Kinase; Translation (biology); RNA interference; Messenger RNA; Cell biology; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001196713,0.0002542757,0.0002483435,0.0001566513,0.0001416176,0.0003222183,0.0001029382,0.00016308,0.001555029],"category_scores_gemma":[0.0001105851,0.0001061997,0.0002099459,0.00008605981,0.0001370399,0.0001529591,0.0001794145,0.0003314366,0.000804686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003484023,"about_ca_system_score_gemma":0.0001568628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003121929,"about_ca_topic_score_gemma":0.0003586894,"domain_scores_codex":[0.9998362,0.00002482365,0.00001394906,0.00004274771,0.00004395473,0.00003827023],"domain_scores_gemma":[0.9999366,0.000008189455,0.00001872796,0.00001219887,0.00001326324,0.00001106171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001334965,0.00001441292,0.0001643125,0.00003755054,0.000002115737,0.00003212915,0.000008401766,0.00002906211,0.9982347,0.0000565687,0.0000367668,0.00125044],"study_design_scores_gemma":[0.00003165102,0.000244035,0.008236356,0.00001015635,0.000009120623,0.0003237123,0.00001681805,0.0009828344,0.9862034,0.00008274441,0.003852052,0.000006949525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811149,0.007424236,0.003911685,0.0001577262,0.0001043069,0.00005777211,0.0009258169,0.0002816223,0.006021932],"genre_scores_gemma":[0.9915076,0.001433132,0.001799537,0.00005135031,0.0000252371,0.00004029318,0.0007725252,0.00002869726,0.004341548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001555029,"threshold_uncertainty_score":0.005202055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02915202599061934,"score_gpt":0.2371057419278434,"score_spread":0.2079537159372241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}