{"id":"W1978221294","doi":"10.1016/j.ceb.2007.02.013","title":"Dynamic control of signaling by modular adaptor proteins","year":2007,"lang":"en","type":"review","venue":"Current Opinion in Cell Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":208,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; National Cancer Institute; Ontario Genomics Institute; Genome Canada","keywords":"Signal transducing adaptor protein; Biology; Effector; Signal transduction; Cell biology; Modular design; Cell signaling; Signaling proteins; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005928952,0.0003950523,0.00104606,0.000322863,0.0000229181,0.000006117119,0.0003074651,0.0007182693,0.00001801401],"category_scores_gemma":[0.00005721414,0.0003642574,0.0003119961,0.0002524585,0.0001131472,0.00000258402,0.00008779469,0.0003700218,0.000005556035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006830422,"about_ca_system_score_gemma":0.0002179563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001058884,"about_ca_topic_score_gemma":0.000002725454,"domain_scores_codex":[0.9974793,0.000354759,0.001018116,0.0006400674,0.0001034912,0.0004042691],"domain_scores_gemma":[0.9989358,0.00004813544,0.0005262952,0.0003591836,0.00005569285,0.00007491177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008751172,0.0004904652,0.00009031201,0.01909344,0.0000653129,0.000001483209,0.00001401742,0.0001579938,0.0658906,0.0001345298,0.0001419345,0.9138324],"study_design_scores_gemma":[0.00088495,0.0001652554,0.000001785581,0.004215803,0.00002600224,0.000002703992,0.000004256344,0.0002370471,0.00257334,0.00003206516,0.991473,0.0003838205],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002160754,0.9869004,0.01039971,0.000004451239,0.0008556541,0.001308488,0.0002707909,0.000007809334,0.00003656365],"genre_scores_gemma":[0.007880637,0.9888784,0.0002424661,0.000005998467,0.0001684243,0.0001889713,0.002575295,0.00004089292,0.00001886813],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.991331,"threshold_uncertainty_score":0.9998809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04471371307559351,"score_gpt":0.3538523905806645,"score_spread":0.309138677505071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}