{"id":"W1978234008","doi":"10.1002/art.21646","title":"DNA topoisomerase I binding to fibroblasts induces monocyte adhesion and activation in the presence of anti–topoisomerase I autoantibodies from systemic sclerosis patients","year":2006,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Fibroblast; Topoisomerase; Flow cytometry; Autoantibody; Antibody; Cell adhesion; Molecular biology; Biology; In vitro; Cell; Immunology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002215086,0.0002169229,0.0004726486,0.0002677768,0.0001443027,0.00006510105,0.0001285012,0.0001305296,0.00002560345],"category_scores_gemma":[0.0002042059,0.0001611656,0.00007296469,0.0003848839,0.00008094884,0.0003267756,0.00006500055,0.000138978,0.00001721116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005209183,"about_ca_system_score_gemma":0.00003727922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003947218,"about_ca_topic_score_gemma":0.00008719852,"domain_scores_codex":[0.9980208,0.0001708976,0.0007155059,0.0003709654,0.0004586562,0.000263185],"domain_scores_gemma":[0.9988572,0.000369898,0.0002718261,0.0003128138,0.00009258215,0.00009566247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001272645,0.0004479568,0.2837152,0.0002506059,0.00006183868,0.000009345908,0.004520052,0.00006493301,0.6466697,0.0001543205,0.001282149,0.06269662],"study_design_scores_gemma":[0.002502229,0.0002035683,0.9062269,0.04060316,0.00003197373,0.00001198981,0.001449837,0.00009803092,0.04858502,0.00008962915,0.000006618317,0.0001910744],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911368,0.007323832,0.00001683444,0.0002908376,0.0001553873,0.0008978064,0.00007174738,0.00004235309,0.00006434821],"genre_scores_gemma":[0.9941025,0.005445568,0.0001382184,0.00007388224,0.00004071951,0.00006233571,0.0001011919,0.0000214604,0.00001416844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6225116,"threshold_uncertainty_score":0.6572144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01537535350459499,"score_gpt":0.2299794342548318,"score_spread":0.2146040807502368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}