{"id":"W1978244150","doi":"10.4161/chan.26775","title":"Gating charge movement precedes ionic current activation in hERG channels","year":2013,"lang":"en","type":"article","venue":"Channels","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Mitacs; Heart and Stroke Foundation of Canada","keywords":"Gating; hERG; Biophysics; Patch clamp; Chemistry; Ionic bonding; Ion channel; Charge (physics); Electrophysiology; Materials science; Potassium channel; Ion; Physics; Neuroscience; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001426584,0.0001744197,0.0003070163,0.0002003712,0.000106158,0.0004055171,0.0002164318,0.0002906567,0.001574835],"category_scores_gemma":[0.0003366705,0.0001154218,0.0002013329,0.0001514732,0.0003255923,0.0005049439,0.0002090156,0.0006299315,0.0002640925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002202022,"about_ca_system_score_gemma":0.00008622639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003612026,"about_ca_topic_score_gemma":0.0002996835,"domain_scores_codex":[0.9998765,0.000009414792,0.000007125409,0.00002691333,0.00004432242,0.00003560748],"domain_scores_gemma":[0.9998211,0.00005609225,0.00004102834,0.00001610904,0.00002903868,0.00003667299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008305669,0.000005280031,0.0003588617,0.00001563812,0.000001683858,0.00008519053,0.0000329744,0.00002487401,0.9984529,0.0001097426,0.0000120869,0.0008176134],"study_design_scores_gemma":[0.00003977645,0.0003669877,0.05406532,0.00000961258,0.00001155927,0.0009162579,0.00008629585,0.001456146,0.9417003,0.0003793478,0.0009492023,0.00001913899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948256,0.0007585658,0.002914518,0.00008135929,0.00001540091,0.00001901375,0.0001140426,0.00006610579,0.001205354],"genre_scores_gemma":[0.9987771,0.0001794224,0.000540612,0.00002927317,0.000006339316,0.000006648084,0.00006605152,0.000009104098,0.0003855446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001574835,"threshold_uncertainty_score":0.005268395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020332873923605,"score_gpt":0.2781263618909116,"score_spread":0.2579230331516755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}