{"id":"W1978244150","doi":"10.4161/chan.26775","title":"Gating charge movement precedes ionic current activation in hERG channels","year":2013,"lang":"en","type":"article","venue":"Channels","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Mitacs; Heart and Stroke Foundation of Canada","keywords":"Gating; hERG; Biophysics; Patch clamp; Chemistry; Ionic bonding; Ion channel; Charge (physics); Electrophysiology; Materials science; Potassium channel; Ion; Physics; Neuroscience; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133851,0.0001645673,0.0002906175,0.0001307006,0.00007272052,0.00001856216,0.00005038778,0.00009187251,0.0004696448],"category_scores_gemma":[0.00007671308,0.0001442499,0.00009968534,0.0002148117,0.00003215238,0.0001691755,0.0000414498,0.0002865307,0.0003223615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001260905,"about_ca_system_score_gemma":0.00004531239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004136847,"about_ca_topic_score_gemma":0.00000118783,"domain_scores_codex":[0.998876,0.00004921425,0.0002463992,0.0002873557,0.0001457756,0.0003952406],"domain_scores_gemma":[0.9995093,0.00004825877,0.0000832279,0.0001921147,0.00007535026,0.00009176957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002970505,0.0009693739,0.005423511,0.00067257,0.0002358694,0.00003781183,0.005331231,0.001495739,0.8632988,0.002272278,0.007839799,0.1121259],"study_design_scores_gemma":[0.004940627,0.001093045,0.06266478,0.001882915,0.00006740203,0.00005359793,0.0006025792,0.01204926,0.9042001,0.01006223,0.001463251,0.0009201905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958717,0.0004190052,0.0001041764,0.001373885,0.0007081219,0.0007971,0.00000112198,0.0000622693,0.0006626626],"genre_scores_gemma":[0.9973418,0.0001177943,0.00002823284,0.0004409685,0.001001093,0.0003402726,0.00004285022,0.00002078245,0.0006662017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1112057,"threshold_uncertainty_score":0.588234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020332873923605,"score_gpt":0.2781263618909116,"score_spread":0.2579230331516755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}