{"id":"W1978254270","doi":"10.1038/modpathol.3880471","title":"p53 Alteration and Chromosomal Instability in Prostatic High-Grade Intraepithelial Neoplasia and Concurrent Carcinoma: Analysis by Immunohistochemistry, Interphase In Situ Hybridization, and Sequencing of Laser-Captured Microdissected Specimens","year":2001,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; SickKids Foundation; Toronto General Hospital; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Pathology; Immunohistochemistry; Laser capture microdissection; Intraepithelial neoplasia; Microdissection; Biology; Chromosome instability; In situ hybridization; Carcinoma in situ; Prostate cancer; Comparative genomic hybridization; Fluorescence in situ hybridization; Prostate; Carcinoma; Cancer; Chromosome; Medicine; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001683448,0.0001935063,0.0005174124,0.000248106,0.00002981185,0.00001266984,0.000037431,0.0001421634,0.000009385896],"category_scores_gemma":[0.0001113141,0.0002045573,0.00003268649,0.0003401817,0.0002388503,0.0000610698,0.00004872581,0.0002437492,1.707946e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002705484,"about_ca_system_score_gemma":0.000116999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002887273,"about_ca_topic_score_gemma":0.0008534267,"domain_scores_codex":[0.9985498,0.0001296227,0.000501946,0.0004967696,0.0001046034,0.0002172987],"domain_scores_gemma":[0.9994356,0.00004018905,0.0001489785,0.0002185009,0.00007506903,0.00008167247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000268137,0.0001624235,0.05947415,0.0001059386,0.00005198415,0.000387108,0.003765981,0.0001452873,0.9349581,0.000004328581,0.000004474057,0.0006720545],"study_design_scores_gemma":[0.009190807,0.0005151671,0.2585481,0.0001359363,0.0004994663,0.001343425,0.0003358751,0.03070173,0.6982645,0.0001278393,0.000005785166,0.0003313537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923513,0.002288781,0.004554809,0.0001515452,0.00004228773,0.0004954303,0.00008756841,0.00001441378,0.00001386854],"genre_scores_gemma":[0.9990704,0.0001272514,0.0002947724,0.00003901351,0.00001459337,0.00002945314,0.0004007784,0.00001624682,0.000007476533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2366936,"threshold_uncertainty_score":0.8341606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007452649877389393,"score_gpt":0.2425392704564415,"score_spread":0.2350866205790521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}