{"id":"W1978254270","doi":"10.1038/modpathol.3880471","title":"p53 Alteration and Chromosomal Instability in Prostatic High-Grade Intraepithelial Neoplasia and Concurrent Carcinoma: Analysis by Immunohistochemistry, Interphase In Situ Hybridization, and Sequencing of Laser-Captured Microdissected Specimens","year":2001,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; SickKids Foundation; Toronto General Hospital; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Pathology; Immunohistochemistry; Laser capture microdissection; Intraepithelial neoplasia; Microdissection; Biology; Chromosome instability; In situ hybridization; Carcinoma in situ; Prostate cancer; Comparative genomic hybridization; Fluorescence in situ hybridization; Prostate; Carcinoma; Cancer; Chromosome; Medicine; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003806972,0.0001480536,0.0002131022,0.001425042,0.0004722166,0.0003893879,0.000290066,0.0002502361,0.0009709899],"category_scores_gemma":[0.0009673085,0.000247633,0.0001512675,0.0006936864,0.0004906228,0.0002782267,0.0002689017,0.0002646077,0.0001540863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206958,"about_ca_system_score_gemma":0.0002744534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001696606,"about_ca_topic_score_gemma":0.003202576,"domain_scores_codex":[0.9997545,0.00005071574,0.00002639158,0.00004782234,0.00007637041,0.00004421136],"domain_scores_gemma":[0.9995065,0.0001994731,0.00008068176,0.0000544509,0.00008606107,0.00007292515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003773226,0.0001495306,0.3972972,0.0001304639,0.0001240743,0.007248367,0.0005362661,0.0001978188,0.5767957,0.0002231502,0.000104925,0.01341938],"study_design_scores_gemma":[0.00003637485,0.0004066279,0.8917243,0.000007467446,0.0001166836,0.01546855,0.0004752094,0.001113151,0.08961177,0.0001076579,0.0009221282,0.00001001813],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983289,0.0005533313,0.0004819796,0.00001688421,0.000003168494,0.000008925534,0.0000528751,0.000007536775,0.0005464266],"genre_scores_gemma":[0.9989719,0.0001841031,0.0005227834,0.00000833283,0.000004941089,0.000008736163,0.00008147836,0.000002676609,0.0002150342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001696606,"threshold_uncertainty_score":0.003373444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007452649877389393,"score_gpt":0.2425392704564415,"score_spread":0.2350866205790521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}