{"id":"W1978261324","doi":"10.4161/21624011.2014.958952","title":"Co-blockade of immune checkpoints and adenosine A<sub>2A</sub>receptor suppresses metastasis","year":2014,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Evidence-based Healthcare Collaborating Agency","keywords":"Blockade; Immune checkpoint; Immune system; Tumor microenvironment; Cancer research; CD8; Adenosine; Immunotherapy; Metastasis; Medicine; T cell; Receptor; CTLA-4; Immunology; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002536807,0.000226305,0.0004040014,0.00008356567,0.00008068512,0.00001208451,0.0002426154,0.000257485,0.00009965243],"category_scores_gemma":[0.0001885792,0.0002148516,0.0001125843,0.0000953182,0.000293841,0.000006825681,0.0001444766,0.0001453585,0.00002541062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008385753,"about_ca_system_score_gemma":0.00004803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000496949,"about_ca_topic_score_gemma":0.000003629317,"domain_scores_codex":[0.9986593,0.0001540507,0.0004007565,0.0003695095,0.0001027805,0.0003135832],"domain_scores_gemma":[0.9991478,0.00005987381,0.0002086306,0.0004300807,0.0000967563,0.00005681471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00015599,0.00008864106,0.0009599663,0.00003807338,0.0001965098,0.00000161057,0.00006038917,0.00001072879,0.9907011,0.0001314991,0.004130154,0.003525338],"study_design_scores_gemma":[0.0009613152,0.0005722508,0.003176884,0.00002268222,0.00005949864,0.00004596468,0.00008173451,0.00001067401,0.9538775,0.00006110016,0.04091475,0.0002156537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813451,0.01650408,0.0006884325,0.0003361783,0.0001721068,0.000115874,0.00003484499,0.00001862634,0.0007848278],"genre_scores_gemma":[0.9972531,0.001383924,0.0005670136,0.0001025273,0.0002052853,0.00001835903,0.0001999026,0.00003379626,0.0002361613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0368236,"threshold_uncertainty_score":0.8761393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006129508302185307,"score_gpt":0.2319664697039346,"score_spread":0.2258369614017493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}