{"id":"W1978266328","doi":"10.1021/jm701561e","title":"Synthesis and Screening of Mono- and Di-Aryl Technetium and Rhenium Metallocarboranes. A New Class of Probes for the Estrogen Receptor","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Chemistry; Rhenium; Estrogen; Estrogen receptor; Isomerization; Yield (engineering); Chemical synthesis; Aryl; Stereochemistry; Combinatorial chemistry; In vitro; Biochemistry; Organic chemistry; Internal medicine; Cancer; Catalysis; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002781911,0.0003721088,0.0003448511,0.0002550976,0.0001309938,0.0001817628,0.0003662689,0.000387971,0.001888897],"category_scores_gemma":[0.0002903825,0.0002177586,0.0001455179,0.0002385335,0.000207025,0.0001878162,0.0001992789,0.0003008704,0.0004820252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002482294,"about_ca_system_score_gemma":0.0001774625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003663335,"about_ca_topic_score_gemma":0.000970307,"domain_scores_codex":[0.9998441,0.00004553714,0.0000101249,0.00003213522,0.00004337501,0.00002475068],"domain_scores_gemma":[0.9998735,0.00002987022,0.00002513972,0.00002149949,0.00002185077,0.00002810129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001564548,0.0000417651,0.0001223023,0.0001009729,0.000007889294,0.00008943883,0.00002707695,0.0001970951,0.9941967,0.000182011,0.00007758872,0.004800684],"study_design_scores_gemma":[0.0001042752,0.0009556768,0.000701852,0.000007454638,0.00002748712,0.0005624518,0.00001645307,0.0003933796,0.9919114,0.00003832698,0.005270453,0.00001089559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613806,0.01164563,0.01608078,0.0002406301,0.00007767385,0.0006328112,0.0008717916,0.0002384623,0.008831664],"genre_scores_gemma":[0.9626315,0.005720092,0.02349917,0.0001830887,0.00003252711,0.0003048902,0.001256879,0.00004105406,0.006330937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888897,"threshold_uncertainty_score":0.006318986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03362255744057271,"score_gpt":0.2886488439015972,"score_spread":0.2550262864610245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}