{"id":"W1978292234","doi":"10.1128/aac.00822-13","title":"Viral Resistance in Hepatitis C Virus Genotype 1-Infected Patients Receiving the NS3 Protease Inhibitor Faldaprevir (BI 201335) in a Phase 1b Multiple-Rising-Dose Study","year":2013,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"NS3; Ribavirin; Virology; Hepatitis C virus; Pegylated interferon; Protease inhibitor (pharmacology); Genotyping; Viral load; Genotype; Medicine; Biology; Virus; Antiretroviral therapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001644047,0.0009406261,0.001469372,0.0003627429,0.0004384092,0.0007446351,0.0003025004,0.0009001765,0.0008916189],"category_scores_gemma":[0.001061845,0.0005325066,0.001075304,0.0003881949,0.0003678437,0.0005286698,0.0002005461,0.00130637,0.0002650571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004696626,"about_ca_system_score_gemma":0.0006152437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008262659,"about_ca_topic_score_gemma":0.00111794,"domain_scores_codex":[0.9993517,0.0003037144,0.0000485272,0.00009635273,0.00008106358,0.0001187796],"domain_scores_gemma":[0.9993836,0.0001061801,0.0001233436,0.00004554613,0.00004325591,0.0002981514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4820406,0.06614535,0.2392413,0.0005389678,0.002378905,0.001138822,0.001012914,0.002119699,0.08193345,0.0001672962,0.001885414,0.1213973],"study_design_scores_gemma":[0.08411081,0.5494046,0.3550962,0.00005029277,0.001037672,0.000960478,0.0001658855,0.002908805,0.004392168,0.0001151914,0.001691233,0.00006666905],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991277,0.0003264965,0.00006826036,0.00003459636,0.0000126903,0.0001517882,0.000110379,0.000008616152,0.0001594269],"genre_scores_gemma":[0.9987527,0.0002036239,0.0002472115,0.000157585,0.00003413623,0.0001034103,0.0003014077,0.000003782089,0.0001961106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001644047,"threshold_uncertainty_score":0.008694649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01818253855359406,"score_gpt":0.296666729272101,"score_spread":0.2784841907185069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}