{"id":"W1978308081","doi":"10.1517/14728222.2011.638626","title":"Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy","year":2012,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Targets","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Insulin-like growth factor 1 receptor; Insulin receptor; Insulin-Like Growth Factor Receptor; Signal transduction; Insulin-like growth factor; Cancer; Carcinogenesis; Growth factor receptor; Receptor; Biology; Cancer research; Growth factor; Medicine; Insulin resistance; Insulin; Internal medicine; Endocrinology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0008525843,0.001693018,0.003028701,0.0003486308,0.0007260098,0.0001254931,0.0008808147,0.001118468,0.001013529],"category_scores_gemma":[0.0001445967,0.000994297,0.001759464,0.0006185166,0.0002003716,0.0002542411,0.0001085964,0.001458118,0.0002000897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000567547,"about_ca_system_score_gemma":0.0007963559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000542822,"about_ca_topic_score_gemma":6.806627e-7,"domain_scores_codex":[0.9938203,0.0006031113,0.001737603,0.001280485,0.0009914332,0.001567139],"domain_scores_gemma":[0.9956398,0.001252556,0.001099158,0.001060433,0.0004164148,0.0005316291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004103633,0.0005126037,0.00001997147,0.001881149,0.001381845,0.00000215612,0.002279688,5.893118e-7,0.0006984246,0.0002420567,0.008098339,0.9844728],"study_design_scores_gemma":[0.001677359,0.000834641,0.00001203362,0.003141316,0.000153289,0.00001330886,0.0001834411,0.00001360336,0.001027909,0.00004767629,0.991743,0.00115239],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001794644,0.9840806,0.000344669,0.0008633188,0.008507568,0.00533966,0.0003995246,0.0003163629,0.0001303538],"genre_scores_gemma":[0.0007103787,0.9823849,0.0004676415,0.004765807,0.006552908,0.003017912,0.0012384,0.0005304631,0.0003315659],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9836447,"threshold_uncertainty_score":0.9998997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1186887029938829,"score_gpt":0.3621873722216677,"score_spread":0.2434986692277848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}