{"id":"W1978330228","doi":"10.1126/science.1171085","title":"Apicomplexan Parasites Co-Opt Host Calpains to Facilitate Their Escape from Infected Cells","year":2009,"lang":"en","type":"article","venue":"Science","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Toxoplasma gondii; Calpain; Proteases; Biology; Plasmodium falciparum; Parasite hosting; Virology; Infectivity; Plasmodium (life cycle); Parasitemia; Host (biology); Microbiology; Malaria; Cell biology; Immunology; Genetics; Antibody; Enzyme; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002226655,0.0001091762,0.00008155521,0.00006583897,0.0001879546,0.00005799502,0.0002024951,0.00005622963,0.00007325483],"category_scores_gemma":[0.00008647549,0.00008835383,0.0000449922,0.0002751522,0.0001679874,0.00000826733,0.0000408199,0.00004799668,0.00008679162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001960325,"about_ca_system_score_gemma":0.0000751597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002843427,"about_ca_topic_score_gemma":0.00002412448,"domain_scores_codex":[0.9990496,0.00003801823,0.0001220105,0.0003898136,0.0001685225,0.000232051],"domain_scores_gemma":[0.9994021,0.00001184974,0.00003466276,0.0003002448,0.00008536355,0.0001657885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002135166,0.0000285038,0.001047048,9.027487e-7,0.000002725689,4.083363e-7,0.0001229899,0.0001137327,0.9932287,0.00001966565,0.00115826,0.004255658],"study_design_scores_gemma":[0.0001681633,0.0002081706,0.1417296,0.000005488012,0.000002203987,0.000001280579,0.00005174487,0.0003572983,0.7981879,0.0001333361,0.05900994,0.0001449601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909163,0.00007183381,0.007108696,0.0004554079,0.0001508108,0.0002053119,0.00005339206,0.00003085394,0.001007361],"genre_scores_gemma":[0.9973924,0.000008724017,0.0006573664,0.001058433,0.00009529863,0.000005358035,0.00006942327,0.000004038412,0.0007089199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1950409,"threshold_uncertainty_score":0.3602965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02094206851344002,"score_gpt":0.2571185152220288,"score_spread":0.2361764467085888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}