{"id":"W1978330228","doi":"10.1126/science.1171085","title":"Apicomplexan Parasites Co-Opt Host Calpains to Facilitate Their Escape from Infected Cells","year":2009,"lang":"en","type":"article","venue":"Science","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Toxoplasma gondii; Calpain; Proteases; Biology; Plasmodium falciparum; Parasite hosting; Virology; Infectivity; Plasmodium (life cycle); Parasitemia; Host (biology); Microbiology; Malaria; Cell biology; Immunology; Genetics; Antibody; Enzyme; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001612013,0.0003065144,0.0002059611,0.0001427403,0.0001418129,0.0004709844,0.0002298669,0.0002345235,0.0007022269],"category_scores_gemma":[0.0001214688,0.0001317449,0.0001427394,0.0001043333,0.0002644064,0.0002337642,0.0002400633,0.0004876498,0.0003546817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002956069,"about_ca_system_score_gemma":0.0001524151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003051333,"about_ca_topic_score_gemma":0.0006756448,"domain_scores_codex":[0.999907,0.00001499837,0.000009570388,0.00001930843,0.00002648544,0.00002265442],"domain_scores_gemma":[0.9999028,0.00001890716,0.00002733754,0.00001715739,0.000009226546,0.00002457561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003839478,0.000007119198,0.00009335116,0.00001063811,0.000001382447,0.00002709279,0.000004893233,0.00001974856,0.9992871,0.00009931428,0.00001607355,0.0003948788],"study_design_scores_gemma":[0.00002349894,0.0000692333,0.002499906,0.000002708621,0.000006501475,0.0002669799,0.00001538603,0.0009754957,0.9944442,0.00005842312,0.001634972,0.000002781886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937,0.001023629,0.003784896,0.0001487087,0.00002100722,0.00001821338,0.0001079158,0.00005976838,0.001135882],"genre_scores_gemma":[0.994006,0.0005670009,0.003353216,0.00005291525,0.00001046664,0.00001747678,0.0001729666,0.00001567908,0.001804327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007022269,"threshold_uncertainty_score":0.002349198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02094206851344002,"score_gpt":0.2571185152220288,"score_spread":0.2361764467085888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}