{"id":"W1978333509","doi":"10.1021/bm201538j","title":"Design and Evaluation of Multifunctional Nanocarriers for Selective Delivery of Coenzyme Q10 to Mitochondria","year":2011,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Nanocarriers; Micelle; Coenzyme Q10; Ethylene glycol; Chemistry; Drug delivery; Mitochondrion; Biophysics; Polymer; Click chemistry; Polymerization; Combinatorial chemistry; Materials science; Organic chemistry; Biochemistry; Aqueous solution; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005195586,0.0004388903,0.0003526651,0.0003052313,0.0001813263,0.0004315184,0.0003248837,0.0006323288,0.0004307667],"category_scores_gemma":[0.0004480422,0.0002317874,0.0003390675,0.0001455743,0.0003308648,0.0003987035,0.0003157697,0.0004088618,0.0003119043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001017766,"about_ca_system_score_gemma":0.0004318258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001348505,"about_ca_topic_score_gemma":0.001089497,"domain_scores_codex":[0.9997306,0.00003056972,0.00003471529,0.00007471913,0.00008102954,0.00004828455],"domain_scores_gemma":[0.9997646,0.0000384294,0.00007206233,0.00002353672,0.00006133625,0.00003992159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006603578,0.00003858911,0.00006949492,0.00003921187,0.000006980675,0.00003519222,0.00001729489,0.0004632701,0.9967733,0.0001394635,0.00002348676,0.002327584],"study_design_scores_gemma":[0.00003389436,0.0003857302,0.0002806894,0.00000360301,0.00001419815,0.00005416804,0.000006815672,0.001889082,0.9961111,0.0000193554,0.001193827,0.000007590651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649192,0.002837219,0.03008711,0.0002289901,0.00006486314,0.0004606676,0.0001786989,0.000159815,0.001063381],"genre_scores_gemma":[0.960294,0.001898174,0.0352415,0.0001082849,0.00001865503,0.0003236967,0.0002457398,0.00004047747,0.001829481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001348505,"threshold_uncertainty_score":0.007384419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04023204148590138,"score_gpt":0.2774160353388861,"score_spread":0.2371839938529847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}