{"id":"W1978333509","doi":"10.1021/bm201538j","title":"Design and Evaluation of Multifunctional Nanocarriers for Selective Delivery of Coenzyme Q10 to Mitochondria","year":2011,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Nanocarriers; Micelle; Coenzyme Q10; Ethylene glycol; Chemistry; Drug delivery; Mitochondrion; Biophysics; Polymer; Click chemistry; Polymerization; Combinatorial chemistry; Materials science; Organic chemistry; Biochemistry; Aqueous solution; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003058483,0.0001156819,0.000145572,0.00005415122,0.00005451181,0.000003198682,0.00007063975,0.00007779701,0.000005363982],"category_scores_gemma":[0.0001401815,0.0001102381,0.00006462482,0.00008751892,0.00008384598,0.000002623502,0.00006095739,0.00001588081,6.469174e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001291272,"about_ca_system_score_gemma":0.00008474611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005758871,"about_ca_topic_score_gemma":0.00002893578,"domain_scores_codex":[0.999215,0.00007181048,0.0001691267,0.000253916,0.0001473718,0.0001427653],"domain_scores_gemma":[0.9991987,0.00003269768,0.00008919344,0.0001349421,0.0004894565,0.00005500529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006737614,0.00005412914,0.0001910299,0.00002717957,0.0001520354,2.849277e-7,0.0002795988,0.00001969198,0.9849073,0.00006299375,0.01258757,0.001044456],"study_design_scores_gemma":[0.0009435255,0.00119577,0.004155279,0.00001716596,0.0001015837,0.000004621147,0.0001161692,0.0003568839,0.9925062,0.0001351456,0.0003438261,0.000123822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9635696,0.001106693,0.03424239,0.00001656844,0.0001346533,0.0008066474,0.00004703529,0.000004632585,0.0000717771],"genre_scores_gemma":[0.9756176,0.0000257159,0.02410111,0.00003422873,0.00004552607,0.0001241017,0.0000254862,0.00001354258,0.00001271354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01224375,"threshold_uncertainty_score":0.4495379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04023204148590138,"score_gpt":0.2774160353388861,"score_spread":0.2371839938529847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}