{"id":"W1978399916","doi":"10.1016/j.yrtph.2010.08.014","title":"Respiratory safety pharmacology: Concurrent validation of volume, rate, time, flow and ratio variables in conscious male Sprague–Dawley rats","year":2010,"lang":"en","type":"article","venue":"Regulatory Toxicology and Pharmacology","topic":"Pharmacological Effects and Assays","field":"Agricultural and Biological Sciences","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"L'Alliance Boviteq; Université de Montréal; Institut National de la Recherche Scientifique","funders":"Infrastructure Canada; National Institutes of Health","keywords":"Safety pharmacology; Pharmacology; Medicine; Volume (thermodynamics); Anesthesia; Toxicology; Biology; Drug","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001673085,0.0003163825,0.0006439159,0.00007539626,0.0002581414,0.00002108894,0.0002385913,0.0005500678,0.007221166],"category_scores_gemma":[0.00007798434,0.0001743431,0.00007162473,0.00030234,0.0009198961,0.0001978756,0.0001937477,0.0006685712,0.00002497035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003387005,"about_ca_system_score_gemma":0.00007218408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001343115,"about_ca_topic_score_gemma":0.0000620706,"domain_scores_codex":[0.996949,0.001188547,0.0006022063,0.0006161873,0.0001190438,0.0005250601],"domain_scores_gemma":[0.99794,0.001334861,0.0002906353,0.00006466208,0.000109775,0.0002600439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000374408,0.0003318764,0.01473567,0.00003673172,0.00006333463,0.00004081658,0.00004200916,0.00006514443,0.9674494,0.0005302064,0.006722585,0.009607842],"study_design_scores_gemma":[0.003427333,0.001545371,0.1785994,0.00001806047,0.0002073749,0.00009597637,0.00003185551,0.005601317,0.7373219,0.0003921005,0.07216524,0.0005941925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953257,0.0005889172,0.000005460249,0.001136343,0.001427637,0.0007846262,0.0001136357,0.00005689258,0.0005607909],"genre_scores_gemma":[0.9969988,0.0002010643,0.00004683452,0.001954016,0.0004205896,0.0000874818,0.00005255194,0.000003772746,0.0002349061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2301275,"threshold_uncertainty_score":0.9936864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326617158790828,"score_gpt":0.2638914079330949,"score_spread":0.2506252363451866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}