{"id":"W1978400037","doi":"10.1016/s0735-1097(12)61605-2","title":"CHRONIC INHIBITION OF PYRUVATE DEHYDROGENASE KINASE WITH DICHLOROACETATE, IMPROVES CARDIAC METABOLISM AND FUNCTION IN RIGHT VENTRICULAR HYPERTROPHY IN FAWN-HOODED RATS","year":2012,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Pyruvate dehydrogenase complex; Pyruvate dehydrogenase kinase; Internal medicine; Myocardial hypertrophy; Ventricular function; Pyruvate kinase; Right ventricular hypertrophy; Cardiac hypertrophy; Muscle hypertrophy; Metabolism; Endocrinology; Cardiology; Enzyme; Glycolysis; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003268475,0.001477132,0.001084183,0.001114712,0.0006274523,0.0006417756,0.0008356594,0.000921097,0.002038145],"category_scores_gemma":[0.0004008552,0.0007676489,0.0005254914,0.000390249,0.001421571,0.001054294,0.0004481142,0.002611178,0.0003804058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007104236,"about_ca_system_score_gemma":0.001086489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004006979,"about_ca_topic_score_gemma":0.007953469,"domain_scores_codex":[0.9996226,0.00003399364,0.00004131737,0.0001052906,0.00004966588,0.0001471084],"domain_scores_gemma":[0.9988651,0.00009738614,0.0002994337,0.0001412066,0.0000718216,0.0005249699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01279745,0.001213397,0.0008024853,0.00008843521,0.00004538465,0.0001875844,0.0000615917,0.0002060379,0.9809914,0.000198034,0.0002092053,0.003198911],"study_design_scores_gemma":[0.001422139,0.008221665,0.01161611,0.00003151993,0.0001978755,0.0003023725,0.0003396669,0.001650939,0.9742483,0.0002570724,0.001663087,0.00004929312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967158,0.0006898098,0.001070996,0.0003456204,0.0001360352,0.00002882526,0.0004330279,0.0001583818,0.000421556],"genre_scores_gemma":[0.9880804,0.001096811,0.002533431,0.0002552674,0.00008394769,0.0001326121,0.0008294653,0.0001278164,0.006860275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004006979,"threshold_uncertainty_score":0.007967293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006158474010919469,"score_gpt":0.222431754544789,"score_spread":0.2162732805338696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}