{"id":"W1978425566","doi":"10.1016/j.abb.2006.08.009","title":"Physical nature of signal peptide binding to DmsD","year":2006,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; University of Calgary","keywords":"Isothermal titration calorimetry; Peptide; Chemistry; Guanidine; Target peptide; Titration; Biochemistry; Protein folding; Folding (DSP implementation); Denaturation (fissile materials); Size-exclusion chromatography; Signal peptide; Arginine; Biophysics; Peptide sequence; Chromatography; Amino acid; Enzyme; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004306533,0.0002705867,0.0003276218,0.0002766892,0.0005856971,0.000520089,0.0005756686,0.0004541282,0.01108722],"category_scores_gemma":[0.001178453,0.0002923883,0.0003407804,0.0002052808,0.0005146921,0.0003878897,0.0003814041,0.001051976,0.001321587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005803771,"about_ca_system_score_gemma":0.0003380748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009064802,"about_ca_topic_score_gemma":0.0008699255,"domain_scores_codex":[0.9996852,0.00004428289,0.0000131664,0.00007609562,0.00009108322,0.0000903464],"domain_scores_gemma":[0.9991351,0.0004490068,0.00007670165,0.00008275507,0.00009078351,0.0001657352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005729659,0.00006917058,0.0004224796,0.00007675194,0.00002334235,0.0002033225,0.00005023823,0.0002884709,0.9941823,0.001652802,0.0002077065,0.00225041],"study_design_scores_gemma":[0.00003816862,0.0001094654,0.003029566,0.00001058613,0.000008352371,0.0001772354,0.00005192532,0.002156352,0.9919336,0.0002441659,0.002229641,0.00001089287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756423,0.0007052383,0.01085303,0.0005130255,0.0001544258,0.00005400024,0.0003455816,0.0001162174,0.0116161],"genre_scores_gemma":[0.9930127,0.0001625029,0.002302451,0.0002409586,0.0000185025,0.00002630509,0.0003980563,0.00003076778,0.003807833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01108722,"threshold_uncertainty_score":0.03709042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003001706688524957,"score_gpt":0.2297923324099572,"score_spread":0.2267906257214323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}