{"id":"W1978425566","doi":"10.1016/j.abb.2006.08.009","title":"Physical nature of signal peptide binding to DmsD","year":2006,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; University of Calgary","keywords":"Isothermal titration calorimetry; Peptide; Chemistry; Guanidine; Target peptide; Titration; Biochemistry; Protein folding; Folding (DSP implementation); Denaturation (fissile materials); Size-exclusion chromatography; Signal peptide; Arginine; Biophysics; Peptide sequence; Chromatography; Amino acid; Enzyme; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000284787,0.0001498369,0.0001885863,0.00002519291,0.00004378765,0.000004450714,0.0001638394,0.0001295538,0.000001920676],"category_scores_gemma":[0.00001765871,0.0001311596,0.0001079271,0.00008095464,0.0003622133,0.000002666477,0.000139086,0.0001168317,7.754102e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001456588,"about_ca_system_score_gemma":0.0000265104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008826387,"about_ca_topic_score_gemma":0.00000132822,"domain_scores_codex":[0.9992947,0.00002197415,0.0001582804,0.000289696,0.00007302068,0.0001623502],"domain_scores_gemma":[0.9995769,0.0000356526,0.0001042481,0.0001975729,0.00003249341,0.00005309012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001504866,0.0001179745,0.003023685,0.0000733112,0.00004128745,9.943926e-7,0.0000331839,0.0000122182,0.9938526,0.0003634185,0.0001611286,0.002169668],"study_design_scores_gemma":[0.0002251858,0.0002180002,0.004296257,0.00004087689,0.00001623016,0.000003389872,0.00005574797,0.00001711468,0.9936015,0.001028267,0.0003505044,0.0001469055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956487,0.0002264757,0.0002325559,0.00004892646,0.00002152858,0.00006879293,0.0001510582,0.000004485923,0.003597517],"genre_scores_gemma":[0.998103,0.00003260528,0.0008869423,0.00002789468,0.0002876107,0.000003993331,0.0002180797,0.000008627221,0.0004312686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003166249,"threshold_uncertainty_score":0.5348535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003001706688524957,"score_gpt":0.2297923324099572,"score_spread":0.2267906257214323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}