{"id":"W1978432281","doi":"10.1124/dmd.107.019661","title":"Modulation of Human Multidrug Resistance Protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) Transport Activities by Endogenous and Exogenous Glutathione-Conjugated Catechol Metabolites","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Multidrug resistance-associated protein 2; ABCC1; Glutathione; Multidrug Resistance-Associated Proteins; Endogeny; Catechol; Chemistry; Biochemistry; Glutathione transferase; Metabolism; Metabolite; Biology; Pharmacology; Enzyme; ATP-binding cassette transporter; Transporter; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196876,0.0002076074,0.0002410606,0.0001225636,0.0001346861,0.0004943628,0.0001315284,0.0002527587,0.001488003],"category_scores_gemma":[0.0003773523,0.0001617508,0.0002161068,0.0001507723,0.0002659707,0.0003192182,0.0001163172,0.0004485727,0.000199361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003749404,"about_ca_system_score_gemma":0.0002440461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007821159,"about_ca_topic_score_gemma":0.0009946162,"domain_scores_codex":[0.9997763,0.00009795863,0.00001529239,0.00002898326,0.00002373286,0.00005781119],"domain_scores_gemma":[0.9997939,0.00007913364,0.00003021121,0.00003230304,0.00002125698,0.00004327223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004051086,0.0002150872,0.0009072294,0.0000551031,0.00003135093,0.0001324132,0.00005658596,0.0001575781,0.9887111,0.0005458129,0.0001028957,0.00503388],"study_design_scores_gemma":[0.0001183703,0.001305107,0.00529951,0.000004041783,0.00003661351,0.0002730176,0.0000412309,0.001398055,0.9902692,0.00007025234,0.001176692,0.000007959079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977744,0.000743088,0.0007174363,0.00007019308,0.00001882452,0.00001122231,0.000111551,0.00001918621,0.0005340133],"genre_scores_gemma":[0.9983429,0.0003041736,0.0004887939,0.00001799774,0.000009134397,0.00001064612,0.0001148925,0.000009888759,0.0007015796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488003,"threshold_uncertainty_score":0.004977882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009004766075231084,"score_gpt":0.2280543106790638,"score_spread":0.2190495446038327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}