{"id":"W1978432281","doi":"10.1124/dmd.107.019661","title":"Modulation of Human Multidrug Resistance Protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) Transport Activities by Endogenous and Exogenous Glutathione-Conjugated Catechol Metabolites","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Multidrug resistance-associated protein 2; ABCC1; Glutathione; Multidrug Resistance-Associated Proteins; Endogeny; Catechol; Chemistry; Biochemistry; Glutathione transferase; Metabolism; Metabolite; Biology; Pharmacology; Enzyme; ATP-binding cassette transporter; Transporter; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005994442,0.0003560786,0.0007014658,0.0002477869,0.00033382,0.00002975814,0.00006122649,0.0001682617,0.00001255031],"category_scores_gemma":[0.000009682733,0.0003159692,0.00009220473,0.0002302613,0.0002843016,0.0003866754,0.00001400588,0.0002088443,4.758474e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002208444,"about_ca_system_score_gemma":0.00003258104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003317291,"about_ca_topic_score_gemma":0.0002427002,"domain_scores_codex":[0.9980259,0.0000595717,0.0005958462,0.0005225963,0.0003967689,0.0003993367],"domain_scores_gemma":[0.9991279,0.00003878358,0.000231082,0.0002482872,0.0001045252,0.0002493946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008463874,0.0002563379,0.001424325,0.0005260319,0.00009015422,0.00004375557,0.004378062,0.000001288499,0.9865903,0.003433924,0.000006680141,0.002402749],"study_design_scores_gemma":[0.003862912,0.00009091198,0.1268951,0.0002715386,0.0006912826,0.00005301406,0.001747117,0.00004188279,0.8638852,0.001195397,0.0008170382,0.0004485816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825683,0.01357883,0.001705994,0.0001166084,0.00007074725,0.001123538,0.0002603993,0.00009806122,0.0004774888],"genre_scores_gemma":[0.9962104,0.0008249789,0.001457359,0.00006506224,0.00008355919,0.00005010462,0.000489555,0.00004793804,0.0007710685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1254708,"threshold_uncertainty_score":0.9999292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009004766075231084,"score_gpt":0.2280543106790638,"score_spread":0.2190495446038327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}