{"id":"W1978477818","doi":"10.1016/j.bbrc.2014.03.068","title":"Basic Tilted Helix Bundle – A new protein fold in human FKBP25/FKBP3 and HectD1","year":2014,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Helix bundle; FKBP; Ubiquitin ligase; Bundle; Conserved sequence; Protein structure; Biology; Sequence motif; Peptide sequence; Biophysics; DNA; Crystallography; Chemistry; Ubiquitin; Cell biology; Genetics; Biochemistry; Gene; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001232249,0.0002948278,0.0003586381,0.0001489007,0.0003844485,0.0002976904,0.0003249856,0.0003921849,0.001053557],"category_scores_gemma":[0.0001694201,0.0001715647,0.0003406569,0.0002416951,0.0003054942,0.000374737,0.0003400368,0.0004524486,0.0003878828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004294303,"about_ca_system_score_gemma":0.0001626764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006232344,"about_ca_topic_score_gemma":0.0005609521,"domain_scores_codex":[0.9999232,0.00001093441,0.000006962779,0.00002268787,0.00001920619,0.00001700267],"domain_scores_gemma":[0.9998621,0.000007909992,0.00004144859,0.00001043423,0.00001253772,0.0000655828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009409084,0.00006487316,0.00259175,0.0001327514,0.00005035731,0.002544302,0.0001470716,0.001261253,0.9840979,0.001527835,0.0009302286,0.005710812],"study_design_scores_gemma":[0.0002812075,0.001785759,0.1212265,0.00006026787,0.0002723732,0.01605462,0.0007266203,0.02492198,0.7948399,0.003450625,0.03620297,0.0001771702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911141,0.001166061,0.005886259,0.0001989607,0.0001027078,0.00002249131,0.000183421,0.0001591217,0.00116694],"genre_scores_gemma":[0.9965504,0.0001327651,0.001816766,0.000116025,0.00002112645,0.00001005332,0.0003112214,0.00001139112,0.001030087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001053557,"threshold_uncertainty_score":0.003524423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06632566146860812,"score_gpt":0.3697082515235887,"score_spread":0.3033825900549805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}