{"id":"W1978496247","doi":"10.1038/sj.gt.3302355","title":"Polyethyleneimine grafted with pluronic P85 enhances Ku86 antisense delivery and the ionizing radiation treatment efficacy in vivo","year":2004,"lang":"en","type":"article","venue":"Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Supratek Pharma (Canada); McGill University; Jewish General Hospital; Montreal General Hospital","funders":"National Cancer Institute; Leukemia and Lymphoma Society; National Science Foundation","keywords":"Transfection; In vivo; Cell culture; Molecular biology; Antisense therapy; Biology; Cell; Oligonucleotide; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009459514,0.0001629105,0.0001504927,0.00004411555,0.00008055402,0.00002741869,0.00008960263,0.0000670035,0.000008414878],"category_scores_gemma":[0.000005147351,0.0001000078,0.00004922183,0.00008573448,0.0001079582,0.000006114735,0.00001755697,0.00004308623,0.000003069406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003170033,"about_ca_system_score_gemma":0.00007791478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003919442,"about_ca_topic_score_gemma":0.0003707206,"domain_scores_codex":[0.9992505,0.00006206977,0.0001435334,0.0002739222,0.00007649685,0.0001934591],"domain_scores_gemma":[0.9996331,0.00001652189,0.00005925641,0.000225591,0.00003030144,0.00003521277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001453198,0.0001083008,0.0004346652,0.000001610956,0.00009543489,0.000008118563,0.0004980672,0.0005967636,0.9710405,0.00001624929,0.00001379773,0.02573327],"study_design_scores_gemma":[0.007406532,0.00116043,0.004780371,0.00001610346,0.00001375707,0.00002318022,0.00009322675,0.00002356316,0.9853501,0.00003754537,0.0009490543,0.0001461508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843163,0.01473308,0.0001673235,0.0003904532,0.00005174919,0.0002859492,0.000006156162,0.000009272268,0.00003968393],"genre_scores_gemma":[0.9652638,0.03401664,0.0001421807,0.0002878889,0.0001185705,0.00003249555,0.0000261534,0.00001475107,0.00009748845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02558712,"threshold_uncertainty_score":0.4078199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009556445323415475,"score_gpt":0.2319212852836569,"score_spread":0.2223648399602414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}