{"id":"W1978496247","doi":"10.1038/sj.gt.3302355","title":"Polyethyleneimine grafted with pluronic P85 enhances Ku86 antisense delivery and the ionizing radiation treatment efficacy in vivo","year":2004,"lang":"en","type":"article","venue":"Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Supratek Pharma (Canada); McGill University; Jewish General Hospital; Montreal General Hospital","funders":"National Cancer Institute; Leukemia and Lymphoma Society; National Science Foundation","keywords":"Transfection; In vivo; Cell culture; Molecular biology; Antisense therapy; Biology; Cell; Oligonucleotide; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002629346,0.0003750113,0.0003189575,0.0002901487,0.0001838475,0.0002522432,0.0001889498,0.0002645086,0.00112887],"category_scores_gemma":[0.0001568407,0.0001861489,0.0002054437,0.0001779561,0.0002662701,0.0002479706,0.0001723277,0.0005098915,0.0002421557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001821065,"about_ca_system_score_gemma":0.0002651507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006162754,"about_ca_topic_score_gemma":0.0004680695,"domain_scores_codex":[0.9998763,0.00002380302,0.000009877819,0.00002346592,0.00002732855,0.00003932336],"domain_scores_gemma":[0.9998453,0.00004749456,0.00004222756,0.00001934914,0.00001330377,0.00003227692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001899104,0.00002403653,0.00004861495,0.0000163436,0.000003273209,0.00001120131,0.00001026415,0.00004452938,0.9988708,0.0000845282,0.00001088758,0.0006856255],"study_design_scores_gemma":[0.000007270086,0.0001808902,0.0005663121,0.000001477988,0.000008927269,0.0000360142,0.000003951584,0.0002302215,0.9986286,0.00001174474,0.0003229455,0.000001688122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952909,0.0009349717,0.002278578,0.00003969037,0.00002134328,0.00002265284,0.00006327683,0.00006990047,0.001278727],"genre_scores_gemma":[0.995906,0.0005009993,0.001095283,0.00001693727,0.000009176914,0.00001411988,0.0001098161,0.00002104651,0.002326627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00112887,"threshold_uncertainty_score":0.003776491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009556445323415475,"score_gpt":0.2319212852836569,"score_spread":0.2223648399602414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}