{"id":"W1978510853","doi":"10.1074/jbc.m504069200","title":"γ-Secretase Is a Functional Component of Phagosomes","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada); Université de Montréal","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; Genome Canada","keywords":"Phagosome; Nicastrin; Cell biology; Presenilin; Phagocytosis; Biology; Chemistry; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132993,0.0004619796,0.000334712,0.0003370426,0.0002618338,0.0004852906,0.0001838685,0.000348748,0.001463563],"category_scores_gemma":[0.0001589613,0.0001503175,0.0003217667,0.0001756384,0.0001357593,0.0003265808,0.0002849219,0.0003281751,0.0008756913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004315355,"about_ca_system_score_gemma":0.0002250242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004697931,"about_ca_topic_score_gemma":0.0003658518,"domain_scores_codex":[0.9998546,0.00001313031,0.00001677646,0.00004643002,0.00004459526,0.00002447371],"domain_scores_gemma":[0.9999037,0.000009419269,0.00002463958,0.00001318556,0.00002462485,0.00002440329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004732047,0.000005770395,0.0004747644,0.00006542548,0.00001115088,0.000149991,0.0000128359,0.00001406039,0.9966117,0.000161045,0.00006095011,0.002385039],"study_design_scores_gemma":[0.00001519573,0.0001466589,0.02558105,0.00003783961,0.00003460192,0.002461879,0.00004822431,0.0007424443,0.9448881,0.0004120317,0.0256202,0.00001176342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9352907,0.02412235,0.0271731,0.000393479,0.0001750906,0.0002017284,0.001973143,0.0004620456,0.01020853],"genre_scores_gemma":[0.9752697,0.004058975,0.007949064,0.0001237084,0.00003626765,0.0000576661,0.0019949,0.0000381613,0.01047152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001463563,"threshold_uncertainty_score":0.004896104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02103251590607108,"score_gpt":0.2560430243443508,"score_spread":0.2350105084382797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}