{"id":"W1978517331","doi":"10.1016/j.bbapap.2005.07.039","title":"Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: Evaluation of their effects on cells and different molecular forms of human CK2","year":2005,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Protein subunit; In vitro; Kinase; Gene isoform; Protein kinase A; Biochemistry; Isozyme; Gene knockdown; Biology; Cell biology; Chemistry; Enzyme; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007573828,0.0009162267,0.001694038,0.0003578926,0.0001426774,0.00005223991,0.0002842364,0.0007440127,0.000004883154],"category_scores_gemma":[0.0001184588,0.0007234769,0.0004455375,0.0003031638,0.0003647807,0.00002727265,0.0002998631,0.0004470462,5.008902e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006496365,"about_ca_system_score_gemma":0.0003538056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002664058,"about_ca_topic_score_gemma":0.000006525593,"domain_scores_codex":[0.9962515,0.0006237344,0.001126886,0.001006047,0.0005862095,0.0004055993],"domain_scores_gemma":[0.9972334,0.00006089889,0.001509337,0.0006793683,0.0003094269,0.0002075696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001730002,0.000381617,6.769765e-7,0.007323669,0.0003347573,0.000001250086,0.0001141861,0.000003086251,0.9126372,0.0002526868,0.000006055778,0.07877179],"study_design_scores_gemma":[0.001623822,0.002525279,0.00003863522,0.006056944,0.0006472584,0.000009870422,0.00002506811,0.00005752095,0.9869195,0.0006875565,0.0007150273,0.0006935598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.798143,0.1941805,0.00003311205,0.0000287178,0.00002719631,0.007255817,0.0002557391,0.00001470183,0.00006130178],"genre_scores_gemma":[0.8463824,0.1517106,0.0005309049,0.00001698552,0.0001626617,0.0007828582,0.0002914568,0.0001099711,0.0000122022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07807823,"threshold_uncertainty_score":0.9995216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01783272422829648,"score_gpt":0.2927982324967857,"score_spread":0.2749655082684893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}