{"id":"W1978518472","doi":"10.1074/jbc.m802648200","title":"Apolipoprotein(a), through Its Strong Lysine-binding Site in KIV10, Mediates Increased Endothelial Cell Contraction and Permeability via a Rho/Rho Kinase/MYPT1-dependent Pathway","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Heart and Stroke Foundation of Canada","keywords":"Myosin-light-chain phosphatase; Phosphorylation; Myosin light-chain kinase; Rho-associated protein kinase; Human umbilical vein endothelial cell; Umbilical vein; Cell biology; Biology; Apolipoprotein B; Rho kinase inhibitor; Kinase; Endothelial stem cell; Actin cytoskeleton; Cytoskeleton; Biochemistry; Molecular biology; Cell; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000150516,0.00035145,0.0001410145,0.0001433904,0.0001196684,0.0002097501,0.0002129781,0.0002434981,0.001073922],"category_scores_gemma":[0.00009970568,0.0001292535,0.0001948653,0.00007837777,0.0002167163,0.0001376835,0.0001924775,0.000458238,0.0005291954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002452025,"about_ca_system_score_gemma":0.0001424721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004255439,"about_ca_topic_score_gemma":0.0006307855,"domain_scores_codex":[0.9998962,0.0000234763,0.00000823614,0.00001901707,0.00002782928,0.00002531214],"domain_scores_gemma":[0.999898,0.00001165258,0.00004066911,0.00001157792,0.00001091381,0.00002720461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007734939,0.00003342966,0.0002246799,0.00003229434,0.0000056956,0.00006836613,0.000006527198,0.00002055397,0.9984968,0.00006228525,0.00006004515,0.0009119533],"study_design_scores_gemma":[0.00006686094,0.0009198138,0.03070301,0.00001672577,0.00003360723,0.001693937,0.00006347859,0.001454947,0.9604592,0.0001739789,0.004402789,0.00001162402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940203,0.001423337,0.002686166,0.000143369,0.00002798839,0.00002785865,0.0001308962,0.000129252,0.001410944],"genre_scores_gemma":[0.9957101,0.0008320861,0.001475494,0.00007197304,0.00001087389,0.00002666454,0.0002141897,0.00001249419,0.001646063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001073922,"threshold_uncertainty_score":0.00359267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01884178093704077,"score_gpt":0.2399068660228163,"score_spread":0.2210650850857755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}