{"id":"W1978526804","doi":"10.1007/s00204-015-1482-0","title":"Enhanced NADPH oxidases and reactive oxygen species in the mechanism of methanol-initiated protein oxidation and embryopathies in vivo and in embryo culture","year":2015,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Prenatal Substance Exposure Effects","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"P22phox; Reactive oxygen species; NADPH oxidase; Chemistry; Oxidative stress; Biochemistry; Protein Carbonylation; Ex vivo; Molecular biology; Biology; In vitro; Lipid peroxidation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003969863,0.0001301031,0.0004046576,0.000277717,0.00001363177,0.000004351285,0.00007443487,0.00009837729,0.000002542869],"category_scores_gemma":[0.0008110221,0.00009595951,0.00001666053,0.0001866304,0.0003057726,0.0001146952,0.00007762819,0.0002091502,1.185963e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001826427,"about_ca_system_score_gemma":0.000049111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007597257,"about_ca_topic_score_gemma":0.001358024,"domain_scores_codex":[0.9987906,0.0004175768,0.0002790541,0.0002263667,0.0001171285,0.0001692761],"domain_scores_gemma":[0.999254,0.0004041302,0.0001368858,0.0001316426,0.00002485627,0.00004852572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001228411,0.0001364539,0.001290091,0.0001390935,0.00001748353,0.00004095309,0.01725876,0.00000103072,0.9761487,0.003149818,0.000003909604,0.0005853452],"study_design_scores_gemma":[0.002377999,0.001352499,0.1361006,0.000313304,0.00001399887,0.00003150999,0.003949481,0.00005318182,0.8480532,0.007662641,0.00000999673,0.0000815741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962031,0.001094247,0.00007866051,0.0003274115,0.0000211687,0.0008857304,0.000010659,0.000007335351,0.001371701],"genre_scores_gemma":[0.9986455,0.0001803193,0.0009707191,0.00006515101,0.00001291496,0.00007146801,0.00000746348,0.000007919833,0.0000385013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1348105,"threshold_uncertainty_score":0.3913115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02433759717987195,"score_gpt":0.2693121734819687,"score_spread":0.2449745763020968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}