{"id":"W1978528400","doi":"10.1210/jc.2012-3851","title":"Theca-Derived BMP4 and BMP7 Down-Regulate Connexin43 Expression and Decrease Gap Junction Intercellular Communication Activity in Immortalized Human Granulosa Cells","year":2013,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Child and Family Research Institute","keywords":"Cell biology; Bone morphogenetic protein 7; SMAD; Bone morphogenetic protein 4; Gene knockdown; Gap junction; Bone morphogenetic protein; Biology; Small interfering RNA; Granulosa cell; Intracellular; Downregulation and upregulation; Smad2 Protein; Cell culture; Chemistry; Endocrinology; Signal transduction; Transfection; Follicular phase; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002113303,0.0002680928,0.0002843235,0.0003311211,0.000150981,0.0002355509,0.0001517331,0.0001874461,0.001235121],"category_scores_gemma":[0.0001796807,0.0001295206,0.0003936632,0.0001561364,0.0002502571,0.00011423,0.0002091553,0.0003745718,0.0002408341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001708298,"about_ca_system_score_gemma":0.0003279443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007681125,"about_ca_topic_score_gemma":0.0009096873,"domain_scores_codex":[0.9998353,0.00003283958,0.00002404772,0.00001962877,0.00005327141,0.00003486752],"domain_scores_gemma":[0.9999188,0.00002019405,0.00002173038,0.00001130393,0.0000109104,0.00001697829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003005911,0.00006480565,0.0005124474,0.00008314611,0.00001179751,0.0001030564,0.00002302894,0.00004679039,0.9968785,0.00006162716,0.00005479274,0.001859469],"study_design_scores_gemma":[0.0000571587,0.000562522,0.008637117,0.00001141935,0.00004695532,0.000347364,0.00006910277,0.0005140721,0.986316,0.0000421582,0.00339252,0.000003565894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937223,0.003217451,0.001203229,0.0001231775,0.00004708026,0.0000590294,0.0002429186,0.000029082,0.001355788],"genre_scores_gemma":[0.9909006,0.003068547,0.002802765,0.0001164788,0.00003024895,0.0001420176,0.0006644066,0.00001540415,0.002259482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235121,"threshold_uncertainty_score":0.004131913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03232125925681378,"score_gpt":0.327341519336204,"score_spread":0.2950202600793903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}