{"id":"W1978558644","doi":"10.1038/mt.2011.132","title":"A Mechanistic Proof-of-concept Clinical Trial With JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients With Metastatic Melanoma","year":2011,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Oncolytic virus; Melanoma; Biology; Virus; Viral replication; Immunology; Cancer research; Virology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008643409,0.0007193212,0.0007694333,0.0001937999,0.0002634045,0.0006277212,0.0004582399,0.0009690459,0.002285822],"category_scores_gemma":[0.000433784,0.0002801357,0.0006261109,0.0001168057,0.0004725064,0.0005470038,0.0002510891,0.001702362,0.0003309286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003648058,"about_ca_system_score_gemma":0.0005815399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002414113,"about_ca_topic_score_gemma":0.000522813,"domain_scores_codex":[0.9998142,0.00007759636,0.00001008816,0.00003524479,0.00002353083,0.00003939479],"domain_scores_gemma":[0.9998263,0.00003486048,0.00004176649,0.00001916033,0.00001368427,0.00006436564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1724984,0.0697318,0.003697114,0.001720557,0.0005571121,0.0007240331,0.0004354124,0.003854898,0.5621739,0.001347977,0.002452258,0.1808065],"study_design_scores_gemma":[0.1185408,0.8342936,0.009468148,0.00009540532,0.0002783366,0.0008215211,0.00008939837,0.001794311,0.02724842,0.0005020897,0.006834581,0.00003334573],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923002,0.001683905,0.001403823,0.0003041223,0.0001054367,0.002007879,0.0003774345,0.00005481704,0.001762466],"genre_scores_gemma":[0.9910909,0.001497038,0.00220314,0.0005242722,0.00007888232,0.001598717,0.000699046,0.00001465656,0.002293314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002285822,"threshold_uncertainty_score":0.007646799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05540121754432453,"score_gpt":0.326185745949199,"score_spread":0.2707845284048745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}