{"id":"W1978558644","doi":"10.1038/mt.2011.132","title":"A Mechanistic Proof-of-concept Clinical Trial With JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients With Metastatic Melanoma","year":2011,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Oncolytic virus; Melanoma; Biology; Virus; Viral replication; Immunology; Cancer research; Virology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00071052,0.0004505149,0.0006469524,0.000180188,0.00006623072,0.00002383353,0.0005480854,0.000210453,0.0001244082],"category_scores_gemma":[0.0001184855,0.0003428046,0.0001874357,0.0003952571,0.0002663103,0.000009935646,0.00007892724,0.0003069082,0.000009007716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004529557,"about_ca_system_score_gemma":0.0004732497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007003802,"about_ca_topic_score_gemma":0.0002122087,"domain_scores_codex":[0.996527,0.0007415771,0.0007266868,0.0008303335,0.0005647262,0.0006096702],"domain_scores_gemma":[0.9982393,0.0000419195,0.0003273344,0.0009035664,0.0002771499,0.0002107391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.7367545,0.01149132,0.004712,0.00008165264,0.002326692,0.0003801986,0.000759519,0.0002254313,0.2065457,0.0002588238,0.00003065639,0.03643356],"study_design_scores_gemma":[0.1170363,0.09645776,0.00155891,0.00006624806,0.0001024494,0.000006458016,0.0000611822,0.0002739729,0.783324,0.0002711051,0.0001435149,0.0006980644],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711851,0.000597076,0.0251999,0.00001409796,0.00009876327,0.002766916,0.00004717666,0.000021021,0.00006993466],"genre_scores_gemma":[0.9912184,0.00002841029,0.007776773,0.000269796,0.00004201853,0.0002981925,0.0001582944,0.0001257557,0.00008238103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6197181,"threshold_uncertainty_score":0.9999024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05540121754432453,"score_gpt":0.326185745949199,"score_spread":0.2707845284048745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}