{"id":"W1978579350","doi":"10.1016/j.bmc.2006.12.041","title":"Design, synthesis, and biological evaluation of substituted 2-alkylthio-1,5-diarylimidazoles as selective COX-2 inhibitors","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"Vanderbilt University","keywords":"Celecoxib; Chemistry; Cyclooxygenase; In vivo; Pharmacology; Carrageenan; Enzyme inhibitor; IC50; Stereochemistry; Chemical synthesis; Aryl; COX-2 inhibitor; Enzyme; Biological activity; In vitro; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00358998,0.0002746385,0.0005088446,0.00008739223,0.0000863887,0.000006112801,0.00009713398,0.0003972193,0.0003329758],"category_scores_gemma":[0.003061875,0.0002140567,0.00006894914,0.0003395507,0.0003747438,0.00004887381,0.00003999949,0.000343821,0.00001651631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002257189,"about_ca_system_score_gemma":0.0005971364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002433845,"about_ca_topic_score_gemma":0.000001958829,"domain_scores_codex":[0.9977489,0.0001156734,0.0005048935,0.0003983415,0.0008495281,0.0003826473],"domain_scores_gemma":[0.9981301,0.0005956749,0.000228147,0.0002445745,0.0004459873,0.0003555608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006704061,0.0001282091,0.01016215,0.0002492136,0.0001038342,0.00008566341,0.0003154039,6.652373e-7,0.9815136,0.00001011441,0.0003122562,0.00644844],"study_design_scores_gemma":[0.001739574,0.0001799292,0.03595582,0.0003557009,0.0004444535,0.0003855157,0.0005072464,0.0001203467,0.9599615,0.0000610854,0.00009301934,0.0001957844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950114,0.002683243,0.0002826757,0.0001672574,0.0001746606,0.0005550072,0.000003414439,0.00007408134,0.001048227],"genre_scores_gemma":[0.9988704,0.0001602136,0.0002001746,0.0001027914,0.0005790435,0.00002288908,0.00002412584,0.0000251475,0.00001519861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02579368,"threshold_uncertainty_score":0.8728978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03123505032033125,"score_gpt":0.2899531863532092,"score_spread":0.2587181360328779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}