{"id":"W1978595257","doi":"10.1007/s00438-011-0612-5","title":"EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases","year":2011,"lang":"en","type":"article","venue":"Molecular Genetics and Genomics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame; Université de Montréal","funders":"Institute of Cancer Research; Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance; Cancer Research UK; Wellcome Trust","keywords":"RAD51; Biology; PALB2; DNA damage; Homologous recombination; DNA repair; Chromatin; Cell biology; G2-M DNA damage checkpoint; Genetics; Replication protein A; BRCA2 Protein; Genome instability; Transcription factor; DNA; Cancer research; DNA-binding protein; Cell cycle checkpoint; Gene; Cell cycle; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008972613,0.0005468925,0.0001958139,0.0003259025,0.0001371388,0.0002377293,0.0001695971,0.0004444986,0.001507267],"category_scores_gemma":[0.00008329198,0.0001293387,0.0002242555,0.0001601886,0.0002871978,0.0001856572,0.0002463472,0.0003844538,0.0002671551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002596816,"about_ca_system_score_gemma":0.0001479582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003029503,"about_ca_topic_score_gemma":0.0005455295,"domain_scores_codex":[0.9998993,0.00002274573,0.00001580095,0.00003009419,0.00001757406,0.00001453633],"domain_scores_gemma":[0.9999123,0.0000199564,0.00003144156,0.00001021151,0.000003206864,0.00002286578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005449744,0.00001426056,0.0001934113,0.00001381427,0.000003886451,0.0001772489,0.000005375586,0.00006376333,0.9990138,0.0001218972,0.00001367355,0.0003242594],"study_design_scores_gemma":[0.00001176814,0.0001140171,0.008152856,0.000005447097,0.00001993355,0.001091142,0.00002732991,0.0007498726,0.9883614,0.00009082609,0.001370689,0.00000467248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916298,0.001572144,0.00482163,0.0001645704,0.000034911,0.00002733316,0.0004532164,0.0001420302,0.001154496],"genre_scores_gemma":[0.9950997,0.0007608283,0.001844067,0.00004779697,0.000008320535,0.00003357771,0.0002602723,0.00002678018,0.00191875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001507267,"threshold_uncertainty_score":0.005042255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170223214016138,"score_gpt":0.2541685151809992,"score_spread":0.2371461937793854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}