{"id":"W1978595257","doi":"10.1007/s00438-011-0612-5","title":"EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases","year":2011,"lang":"en","type":"article","venue":"Molecular Genetics and Genomics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame; Université de Montréal","funders":"Institute of Cancer Research; Canadian Institutes of Health Research; Canadian Breast Cancer Research Alliance; Cancer Research UK; Wellcome Trust","keywords":"RAD51; Biology; PALB2; DNA damage; Homologous recombination; DNA repair; Chromatin; Cell biology; G2-M DNA damage checkpoint; Genetics; Replication protein A; BRCA2 Protein; Genome instability; Transcription factor; DNA; Cancer research; DNA-binding protein; Cell cycle checkpoint; Gene; Cell cycle; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004842036,0.0002126736,0.0001461522,0.00004422764,0.0002068959,0.000065049,0.0004247366,0.0001456884,0.000006794146],"category_scores_gemma":[0.0001756416,0.0001558686,0.0001296952,0.00009618298,0.0001287899,0.000006070166,0.000228337,0.0000909392,0.0000021592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003162884,"about_ca_system_score_gemma":0.0001278539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001397818,"about_ca_topic_score_gemma":0.00002142854,"domain_scores_codex":[0.9986026,0.0002459281,0.0002917784,0.0004645622,0.0001128817,0.0002822572],"domain_scores_gemma":[0.9988612,0.00005818149,0.0001148895,0.0008091403,0.0000751191,0.00008147865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002082491,0.0001845841,0.0008354877,0.00001963149,0.00002826507,0.000004164884,0.0005891668,0.0000310175,0.9937647,0.002383598,0.00004034124,0.001910791],"study_design_scores_gemma":[0.00105749,0.0009300051,0.1238676,0.0000208587,0.00005166192,0.00006474376,0.0004681622,0.0004450354,0.8389851,0.02393326,0.009784489,0.000391533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949673,0.001166365,0.001779351,0.000691196,0.00006944669,0.00100433,0.0001428887,0.00001147165,0.0001675842],"genre_scores_gemma":[0.9977243,0.0001576359,0.001144956,0.0004281092,0.00003577438,0.0002820346,0.0001357528,0.00003850315,0.00005295633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1547796,"threshold_uncertainty_score":0.6356136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170223214016138,"score_gpt":0.2541685151809992,"score_spread":0.2371461937793854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}