{"id":"W1978599264","doi":"10.1016/j.bmcl.2007.01.116","title":"A new platinum complex of triazine demonstrates G1 arrest with novel biological profile in human breast cancer cell line, MDA-MB-468","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Trois-Rivières; College of the North Atlantic; Memorial University of Newfoundland","funders":"","keywords":"Chemistry; Apoptosis; Superoxide dismutase; SOD1; Cisplatin; Cell culture; Cancer cell; Cancer; Biochemistry; Cancer research; Biology; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007602632,0.0002025558,0.0003006645,0.0001642006,0.0001400665,0.000188153,0.0003370935,0.0002807996,0.001223973],"category_scores_gemma":[0.0001174446,0.0001228362,0.0001060598,0.0002050415,0.00012844,0.0001821992,0.0001278155,0.0003019725,0.0002594035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002251895,"about_ca_system_score_gemma":0.0001242129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006231765,"about_ca_topic_score_gemma":0.0009830513,"domain_scores_codex":[0.9999444,0.000007544344,0.000004088667,0.00001741003,0.0000146984,0.00001190706],"domain_scores_gemma":[0.9999572,0.000007178141,0.00001089314,0.000006744912,0.000005655495,0.00001238748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001568032,0.00002542965,0.00009522666,0.00004768451,0.000008593486,0.00007302604,0.00002198102,0.00005731454,0.9974931,0.00008637416,0.0001234125,0.001810963],"study_design_scores_gemma":[0.00004404642,0.0006494643,0.001197072,0.000003268091,0.00002467674,0.0005737714,0.00001053585,0.00042417,0.9947566,0.00002254065,0.002290064,0.000003950282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895706,0.00318958,0.003306459,0.0001617897,0.00003730511,0.00005959453,0.0002990214,0.0002008955,0.003174687],"genre_scores_gemma":[0.994267,0.0008477268,0.00154332,0.00004935774,0.000008893569,0.00001639815,0.0003648073,0.00001968878,0.002882817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223973,"threshold_uncertainty_score":0.004094601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02419553291671482,"score_gpt":0.2533227068259588,"score_spread":0.229127173909244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}