{"id":"W1978614448","doi":"10.1089/10430340252792521","title":"Immunoinhibitory DNA Vaccine Protects Against Autoimmune Diabetes Through cDNA Encoding a Selective CTLA-4 (CD152) Ligand","year":2002,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Diabetes Association; Juvenile Diabetes Research Foundation International","keywords":"Biology; Molecular biology; Cytotoxic T cell; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514972,0.0004744995,0.0003896714,0.0002920982,0.00009269678,0.0002964807,0.0002550137,0.0003709134,0.001037176],"category_scores_gemma":[0.0001086846,0.0001470166,0.0002442233,0.000132263,0.0002182708,0.0001625405,0.0001709997,0.0008872654,0.0003470186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002452415,"about_ca_system_score_gemma":0.0002443779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002823709,"about_ca_topic_score_gemma":0.0003571226,"domain_scores_codex":[0.9998022,0.00002815266,0.0000186607,0.00004032283,0.00004240014,0.00006819306],"domain_scores_gemma":[0.9998701,0.00002386248,0.00003890997,0.00001141377,0.00001331903,0.00004248632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002133787,0.0001951801,0.0000932363,0.00002832331,0.000007793509,0.00002067998,0.000007810445,0.00008173517,0.9980719,0.00008479779,0.00003467383,0.001160428],"study_design_scores_gemma":[0.0001180036,0.002586439,0.00162555,0.00001272619,0.00005654329,0.0001484797,0.0000174349,0.001154461,0.9919723,0.00005197946,0.002251095,0.000005027844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968734,0.0005321045,0.001435573,0.00008448218,0.00006766411,0.00004000968,0.0001426093,0.0001018622,0.000722364],"genre_scores_gemma":[0.9941551,0.0005696674,0.001852077,0.0001033996,0.00003523753,0.00007247773,0.0005660126,0.00002779565,0.002618244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001037176,"threshold_uncertainty_score":0.003469706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02309590376879658,"score_gpt":0.2337682313407135,"score_spread":0.2106723275719169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}