{"id":"W1978633821","doi":"10.1038/mp.2010.99","title":"A functional alternative splicing mutation in human tryptophan hydroxylase-2","year":2010,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Medical Research Council; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; National Institutes of Health; National Center for Research Resources; National Institute of Mental Health; Medical Research Council; Duke-NUS Medical School; National Alliance for Research on Schizophrenia and Depression; AstraZeneca","keywords":"TPH2; Tryptophan hydroxylase; Serotonergic; Alternative splicing; Biology; Exon; Tyrosine hydroxylase; Genetics; Gene; Serotonin; Neuroscience; Dopamine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001844749,0.001185149,0.0005018497,0.00044296,0.0004914965,0.0002648745,0.000485768,0.001278594,0.002950184],"category_scores_gemma":[0.001154039,0.0001414269,0.0006244069,0.0003537361,0.0005474261,0.0001537218,0.0003335114,0.000613314,0.0005310412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002859666,"about_ca_system_score_gemma":0.0002767008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002287343,"about_ca_topic_score_gemma":0.001927156,"domain_scores_codex":[0.9997284,0.00004948183,0.0000424773,0.00009499238,0.0000607622,0.00002391507],"domain_scores_gemma":[0.9995414,0.00021438,0.00009749195,0.00002518089,0.00003270106,0.00008894427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002373169,0.0005718314,0.03295801,0.0002335583,0.0005397756,0.3045633,0.0009797311,0.001196587,0.616296,0.003536578,0.003296277,0.03345529],"study_design_scores_gemma":[0.001720022,0.00443575,0.2759682,0.0001809534,0.0007297976,0.5704463,0.0005894841,0.007105905,0.1208028,0.003407629,0.01440592,0.0002071926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930333,0.0005990475,0.00298593,0.0006652914,0.0002663688,0.0001047837,0.0008994617,0.0001024231,0.001343369],"genre_scores_gemma":[0.997225,0.0001106963,0.001063649,0.0002504309,0.0001148437,0.0000236514,0.0002943568,0.00002284952,0.0008945035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002950184,"threshold_uncertainty_score":0.009869397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01724391214466078,"score_gpt":0.285438191747769,"score_spread":0.2681942796031083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}