{"id":"W1978675534","doi":"10.1093/cvr/cvr036","title":"Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47phox NADPH oxidase subunit","year":2011,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"NADPH oxidase; Pressure overload; Superoxide; Internal medicine; Endocrinology; Angiotensin II; Ventricular remodeling; Knockout mouse; Oxidase test; P22phox; Chemistry; Oxidative stress; Muscle hypertrophy; Biology; Heart failure; Medicine; Biochemistry; Enzyme; Receptor; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004658754,0.0002471545,0.0009970344,0.0002955685,0.0001250995,0.00001402085,0.0006080676,0.0002148391,0.0001170163],"category_scores_gemma":[0.001444724,0.0001764417,0.0009759977,0.001840337,0.0004415741,0.00005866586,0.0007423052,0.0006087736,0.00009490765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003112676,"about_ca_system_score_gemma":0.0001912944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002383454,"about_ca_topic_score_gemma":0.0002096894,"domain_scores_codex":[0.9944162,0.001508817,0.0005687957,0.0007785858,0.00195846,0.0007691301],"domain_scores_gemma":[0.995954,0.0001870135,0.00006200828,0.002336964,0.001183771,0.0002762602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001358398,0.00115559,0.05007653,0.0007477552,0.004305406,0.0002664545,0.009242173,0.000005301193,0.916558,0.00004218097,0.00940648,0.006835775],"study_design_scores_gemma":[0.001863582,0.0003268313,0.07072816,0.0006545712,0.0001571378,0.00003374851,0.0009280293,0.00001247925,0.9224994,0.00003827785,0.002558484,0.0001992598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917108,0.004035894,0.0003292085,0.0004504092,0.0001303024,0.002343984,0.00006911087,0.00002827652,0.0009020176],"genre_scores_gemma":[0.9984834,0.0001432886,0.0001909927,0.00004778166,0.00007367239,0.0001184509,0.000008320464,0.000045462,0.0008886848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02065163,"threshold_uncertainty_score":0.7195085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08470502938905622,"score_gpt":0.3453187218772974,"score_spread":0.2606136924882412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}