{"id":"W1978742734","doi":"10.1371/journal.pone.0062190","title":"Chronic Treatment with the AMP-Kinase Activator AICAR Increases Glycogen Storage and Fatty Acid Oxidation in Skeletal Muscles but Does Not Reduce Hyperglucagonemia and Hyperglycemia in Insulin Deficient Rats","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Internal medicine; Endocrinology; Glycogen; Glycolysis; Insulin; Hyperglucagonemia; AMPK; Glycogen synthase; Glycogen phosphorylase; Glucagon; Chemistry; AMP-activated protein kinase; Glycogenesis; Biology; Protein kinase A; Kinase; Medicine; Metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374664,0.0007323882,0.0005073971,0.0004282846,0.0001457714,0.0003050969,0.0002364082,0.0003814822,0.001387854],"category_scores_gemma":[0.0001286284,0.0002692149,0.0003949393,0.0002189069,0.000324187,0.0003180132,0.000213464,0.001001762,0.0002386266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001919228,"about_ca_system_score_gemma":0.0002435369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006987056,"about_ca_topic_score_gemma":0.001372216,"domain_scores_codex":[0.999854,0.00001496555,0.00002073398,0.00003583789,0.00003029474,0.00004419366],"domain_scores_gemma":[0.9997585,0.00001800592,0.00009452279,0.00003098945,0.00001954636,0.00007835468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001693684,0.0001358245,0.000386624,0.00005721985,0.00002351027,0.00005608588,0.00001286441,0.00004138851,0.9956297,0.00002859308,0.00003065724,0.001903898],"study_design_scores_gemma":[0.0002791617,0.006177313,0.02000371,0.00002676038,0.0001356992,0.0002864482,0.00009388892,0.0006629372,0.9707386,0.00007632715,0.001503246,0.00001589773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973637,0.001259258,0.0007379093,0.00007792152,0.00003689812,0.00001134955,0.0001721622,0.00005261684,0.0002882567],"genre_scores_gemma":[0.9932204,0.002120247,0.001844203,0.0001202643,0.00003839363,0.00006111016,0.0007026101,0.00003146419,0.001861322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001387854,"threshold_uncertainty_score":0.004642844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502888497016254,"score_gpt":0.2125349331091026,"score_spread":0.1975060481389401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}