{"id":"W1978746246","doi":"10.1089/hum.2010.012","title":"Characterization of Anti-HIV Activity Mediated by R88-APOBEC3G Mutant Fusion Proteins in CD4 <sup>+</sup> T cells, Peripheral Blood Mononuclear Cells, and Macrophages","year":2010,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; Public Health Agency of Canada; University of Manitoba","funders":"Canadian Institutes of Health Research; China Scholarship Council; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Manitoba Medical Service Foundation; Manitoba Health Research Council","keywords":"Mutant; Peripheral blood mononuclear cell; APOBEC3G; Biology; Virology; Fusion protein; Cell fusion; Virus; Transfection; Molecular biology; Recombinant DNA; Cell culture; In vitro; Viral replication; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001566026,0.0001515752,0.0001666145,0.00009792556,0.00009259411,0.0001462564,0.0001249088,0.0002348548,0.0002883886],"category_scores_gemma":[0.0001044134,0.00006426485,0.0001664159,0.00009796087,0.00009078655,0.00008613156,0.00008782769,0.0002664613,0.0001783327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001015995,"about_ca_system_score_gemma":0.00009583976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003956953,"about_ca_topic_score_gemma":0.0003430324,"domain_scores_codex":[0.99991,0.00002244548,0.000007639405,0.00001391951,0.0000231327,0.00002289588],"domain_scores_gemma":[0.9999388,0.0000142678,0.00001104652,0.000008630815,0.00001515576,0.00001204482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005071893,0.00001085587,0.0002769924,0.00001075794,0.000002402179,0.00002767895,0.000009576653,0.00002308203,0.9991559,0.00001046021,0.000006765569,0.0004148592],"study_design_scores_gemma":[0.00004231048,0.0008009119,0.01034642,0.000005447062,0.00002666974,0.0007587782,0.00006492282,0.001086459,0.9854826,0.0000438204,0.001336505,0.000005202037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982488,0.0005164109,0.0008603513,0.0000313245,0.000004264739,0.00001612129,0.00009779945,0.00001054221,0.0002143538],"genre_scores_gemma":[0.9960776,0.0004011932,0.002508234,0.00004605119,0.000008576473,0.00003660857,0.0003922037,0.000006570432,0.0005230537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003956953,"threshold_uncertainty_score":0.0009647608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009008704276052179,"score_gpt":0.2275053926364457,"score_spread":0.2184966883603935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}