{"id":"W1978746246","doi":"10.1089/hum.2010.012","title":"Characterization of Anti-HIV Activity Mediated by R88-APOBEC3G Mutant Fusion Proteins in CD4 <sup>+</sup> T cells, Peripheral Blood Mononuclear Cells, and Macrophages","year":2010,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; Public Health Agency of Canada; University of Manitoba","funders":"Canadian Institutes of Health Research; China Scholarship Council; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Manitoba Medical Service Foundation; Manitoba Health Research Council","keywords":"Mutant; Peripheral blood mononuclear cell; APOBEC3G; Biology; Virology; Fusion protein; Cell fusion; Virus; Transfection; Molecular biology; Recombinant DNA; Cell culture; In vitro; Viral replication; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001883458,0.0002301885,0.0003333026,0.0001203853,0.0002024075,0.00002340182,0.0001641424,0.0002411654,0.001274384],"category_scores_gemma":[0.000004973602,0.0001922808,0.00005467123,0.0001131044,0.0002316567,0.00009712009,0.00005930693,0.0003648358,0.00007978244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001957939,"about_ca_system_score_gemma":0.00004435467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002479407,"about_ca_topic_score_gemma":0.00005684965,"domain_scores_codex":[0.9986932,0.0002532369,0.0002392864,0.0003613095,0.00007130569,0.0003816672],"domain_scores_gemma":[0.9994651,0.00002729036,0.0001183924,0.0002915118,0.00004659434,0.00005110666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003146481,0.001111253,0.002047124,0.00001702801,0.0001223098,0.00002168087,0.001293679,0.000001937812,0.9920204,0.000004706023,0.0000554116,0.002989769],"study_design_scores_gemma":[0.004050429,0.000628677,0.02698219,0.00001101447,0.00001194769,0.00001188594,0.00004015507,0.00002237219,0.9664213,0.000007432136,0.001648868,0.0001637115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981323,0.000456938,0.00001092798,0.00007705214,0.00005361997,0.0007468357,0.0004398681,0.00004189989,0.00004055195],"genre_scores_gemma":[0.9969088,0.001791117,0.00004679491,0.00002630191,0.00002629739,0.00004750829,0.0006150993,0.00003362736,0.0005044171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02559914,"threshold_uncertainty_score":0.9996386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009008704276052179,"score_gpt":0.2275053926364457,"score_spread":0.2184966883603935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}