{"id":"W1978812626","doi":"10.1039/c4cc03299c","title":"Fluoro-glycosyl acridinones are ultra-sensitive active site titrating agents for retaining β-glycosidases","year":2014,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Glycosyl; Fluorophore; Chemistry; Stoichiometry; Glycoside hydrolase; Combinatorial chemistry; Biochemistry; Enzyme; Organic chemistry; Fluorescence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001886475,0.0002846566,0.0003763827,0.00003158597,0.0005004914,0.00007939793,0.0008029724,0.0002383709,0.0001091186],"category_scores_gemma":[0.002032242,0.0003039941,0.0002528094,0.0001580894,0.000271426,0.0001460942,0.0002288227,0.0004306804,0.00002914995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000130728,"about_ca_system_score_gemma":0.00003886817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001903773,"about_ca_topic_score_gemma":0.00001132479,"domain_scores_codex":[0.9985535,0.00005728531,0.0004044074,0.0004163654,0.0001787868,0.0003896248],"domain_scores_gemma":[0.995102,0.002531019,0.0002842383,0.001656014,0.0002538885,0.0001728244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005264923,0.0001229129,0.0002270185,0.0001009322,0.00007403726,9.074112e-7,0.0007146363,0.000003986713,0.9948121,0.0004056862,0.0004467219,0.003038464],"study_design_scores_gemma":[0.0003865737,0.000007152628,0.00003670589,0.0002074864,0.0001019905,0.00001035247,0.001354243,0.002380204,0.9852791,0.0004156651,0.009474426,0.0003461208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9343805,0.0001169147,0.0003661294,0.001125224,0.00002822463,0.0001509829,0.0003802416,0.0002407204,0.06321111],"genre_scores_gemma":[0.9958653,0.00005654454,0.002275944,0.0001960191,0.0002030922,0.000216147,0.0007452852,0.00005084267,0.0003907737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06282034,"threshold_uncertainty_score":0.9999412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04764541932777515,"score_gpt":0.285047372985578,"score_spread":0.2374019536578028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}