{"id":"W1978815390","doi":"10.1160/th03-01-0045","title":"Affinity and kinetics of P-selectin binding to heparin","year":2003,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"Chinese Academy of Sciences","keywords":"P-selectin; Heparin; Selectin; Chemistry; Surface plasmon resonance; Biophysics; Platelet; L-selectin; Endothelium; Adhesion; Receptor–ligand kinetics; Platelet membrane glycoprotein; Kinetics; Dissociation constant; Molecular biology; Glycoprotein; Biochemistry; Platelet activation; Immunology; Biology; Endocrinology; Receptor; Materials science; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000217853,0.0001063602,0.0003047986,0.0001494637,0.00004784194,0.0000186831,0.00003738544,0.00006022712,0.0002403345],"category_scores_gemma":[0.0002719939,0.00009418567,0.00003362243,0.0003383251,0.00008144715,0.00002128472,0.0000677645,0.0001144995,0.00001247969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002535681,"about_ca_system_score_gemma":0.00002684614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006939856,"about_ca_topic_score_gemma":0.00002718247,"domain_scores_codex":[0.9990877,0.00005414262,0.0001896841,0.0002227782,0.0002266159,0.0002190923],"domain_scores_gemma":[0.9993685,0.00009592736,0.00003611495,0.0001900701,0.00008346257,0.0002259593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001244155,0.0003439807,0.08554997,0.0002590494,0.0001099893,0.000009195122,0.0007339481,0.000001255283,0.8718218,0.001179351,0.00444039,0.03542661],"study_design_scores_gemma":[0.001007012,0.0007084592,0.1542291,0.00008129964,0.0000850634,0.00002507039,0.0002915462,0.00001595315,0.8324704,0.0000761771,0.01087015,0.0001397634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935471,0.0001934273,0.00007554773,0.0008893402,0.00001834801,0.0002758815,0.000008327683,0.00001456068,0.004977404],"genre_scores_gemma":[0.9933788,0.0007214397,0.00537693,0.0002284135,0.0000104032,0.000006314251,0.000003330493,0.00001695909,0.0002573969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0686791,"threshold_uncertainty_score":0.384078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08712107063651532,"score_gpt":0.3609302963769561,"score_spread":0.2738092257404408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}