{"id":"W1978815542","doi":"10.1016/j.antiviral.2007.06.010","title":"Protease inhibitor resistance in HIV-infected patients: Molecular and clinical perspectives","year":2007,"lang":"en","type":"review","venue":"Antiviral Research","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"","keywords":"Ritonavir; Drug resistance; Protease; Protease inhibitor (pharmacology); Virology; Biology; Drug; Human immunodeficiency virus (HIV); Virus; Genetics; Viral load; Pharmacology; Antiretroviral therapy; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007261203,0.001016747,0.00234723,0.00161977,0.0002278772,0.001293839,0.001061543,0.001460526,0.00318239],"category_scores_gemma":[0.0007786189,0.0002338868,0.0005435116,0.002188869,0.000467662,0.001451416,0.0004191004,0.002102753,0.001623243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004659214,"about_ca_system_score_gemma":0.001025181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007287071,"about_ca_topic_score_gemma":0.001950646,"domain_scores_codex":[0.9997846,0.00004173409,0.00002919147,0.00003933648,0.00008320405,0.00002193393],"domain_scores_gemma":[0.9995776,0.0002296371,0.00006064247,0.000009421227,0.00009209443,0.00003064191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001480856,0.000105021,0.0003228806,0.008851888,0.00009840413,0.0003908617,0.00003497862,0.000234859,0.001428502,0.002572858,0.03018589,0.9556258],"study_design_scores_gemma":[0.0001021489,0.0002393839,0.002140783,0.004443522,0.0003319935,0.004257744,0.00009533446,0.0001915283,0.0005198254,0.002752397,0.9848933,0.00003202041],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006470591,0.9990759,0.00005648175,0.0002620814,0.0001100365,0.000001825914,0.000007766964,0.000003145691,0.0004181158],"genre_scores_gemma":[0.0003497954,0.9989288,0.0001148068,0.0001790308,0.0001984823,0.000002844725,0.00001224984,4.402247e-7,0.0002135061],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00318239,"threshold_uncertainty_score":0.0106461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1083616495597315,"score_gpt":0.4797336593086232,"score_spread":0.3713720097488917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}