{"id":"W1978830674","doi":"10.1074/jbc.m600169200","title":"Heparin Synergistically Enhances Interleukin-11 Signaling through Up-regulation of the MAPK Pathway","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"MAPK/ERK pathway; Heparin; Signal transduction; Interleukin 1β; Cell biology; Chemistry; Interleukin; Biology; Cytokine; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001990478,0.0007864082,0.000508249,0.0004463441,0.0001400141,0.0003145693,0.0002353514,0.0002988777,0.001570693],"category_scores_gemma":[0.000128051,0.0002017605,0.0004352978,0.0002201028,0.0002935701,0.0002775061,0.000267337,0.001123552,0.0002633535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349234,"about_ca_system_score_gemma":0.0004039341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004180538,"about_ca_topic_score_gemma":0.001437875,"domain_scores_codex":[0.9996343,0.00007608521,0.00003062562,0.00003441385,0.0001136558,0.0001109032],"domain_scores_gemma":[0.99986,0.00002291446,0.00004067571,0.00001400525,0.00001474715,0.00004763416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001203398,0.0004839266,0.0002936312,0.0001121451,0.0000187826,0.0001116786,0.00002239138,0.000112243,0.9939744,0.00009056973,0.0001126557,0.003464099],"study_design_scores_gemma":[0.0001254378,0.004812117,0.004095626,0.00001329455,0.00006682881,0.0002776417,0.00004120149,0.001061098,0.9869429,0.00007235751,0.002481204,0.00001022918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931989,0.002405101,0.001914464,0.0002532248,0.0001049058,0.00009644883,0.0002274892,0.00008803887,0.001711309],"genre_scores_gemma":[0.9902475,0.002275611,0.003302301,0.0001061645,0.00005680447,0.0001100533,0.0004290528,0.00001251861,0.003459942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001570693,"threshold_uncertainty_score":0.005254507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0276493796723723,"score_gpt":0.27090637001798,"score_spread":0.2432569903456077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}