{"id":"W1978835230","doi":"10.1080/10428190310001617295","title":"Clinico-Biological Features and Prognostic Significance of PML/RARα Isoforms in Adult Patients with Acute Promyelocytic Leukemia Treated with All Trans Retinoic Acid (ATRA) and Chemotherapy","year":2003,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Acute promyelocytic leukemia; Gene isoform; Clinical significance; Interquartile range; Internal medicine; Exon; Retinoic acid; Medicine; Gastroenterology; Chemotherapy; Oncology; Immunology; Biology; Pathology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000429007,0.0002461235,0.0003758775,0.0008212923,0.0003735968,0.0004868398,0.0002044276,0.0004128373,0.0005669689],"category_scores_gemma":[0.002179628,0.000242447,0.0002047674,0.0007118813,0.0003978602,0.0003782866,0.000241433,0.0003174546,0.0001959381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002355264,"about_ca_system_score_gemma":0.0001424264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005044158,"about_ca_topic_score_gemma":0.0005943992,"domain_scores_codex":[0.9995752,0.000117885,0.00007252816,0.00007918737,0.00008652151,0.00006869611],"domain_scores_gemma":[0.9983449,0.0003863345,0.0008164529,0.00007739458,0.0001009911,0.0002739126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004623307,0.00002553006,0.9951634,0.000006046268,0.00001641505,0.0008801855,0.000072476,0.00006220034,0.00130037,0.000008586599,0.00003264759,0.001969746],"study_design_scores_gemma":[0.00002309749,0.0003077813,0.9928166,0.000006042863,0.00002261795,0.006013856,0.0001111666,0.0001976571,0.0003118869,0.00002653193,0.0001574778,0.000005299029],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993278,0.0003703549,0.00004722592,0.00002424187,0.000001930541,0.000003729963,0.00004494161,0.000003150261,0.0001766761],"genre_scores_gemma":[0.9996662,0.00009663239,0.00006472809,0.00001546804,0.00001457454,0.000004854227,0.00008946499,8.287577e-7,0.00004726309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008212923,"threshold_uncertainty_score":0.002268791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005151419378616752,"score_gpt":0.210969865421691,"score_spread":0.2058184460430743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}