{"id":"W1978846091","doi":"10.1016/j.ab.2011.05.005","title":"Mapping protein interactions by combining antibody affinity maturation and mass spectrometry","year":2011,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Wellcome Trust; National Eye Institute; National Institutes of Health; National Institute of General Medical Sciences; Ontario Genomics Institute; Genome Canada","keywords":"Epitope; Immunoprecipitation; Antibody; Phage display; Biology; Computational biology; Linear epitope; Monoclonal antibody; Immunoglobulin light chain; Molecular biology; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001151324,0.0008775762,0.0008127461,0.0009569055,0.0003522581,0.000986713,0.0009015111,0.0007132915,0.0008332498],"category_scores_gemma":[0.0007867024,0.0005161586,0.0004663646,0.0007171773,0.0003652672,0.0005577134,0.001014698,0.001113162,0.001194819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005141123,"about_ca_system_score_gemma":0.0003244631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005157485,"about_ca_topic_score_gemma":0.001127067,"domain_scores_codex":[0.9986436,0.000202362,0.00007005806,0.0003157964,0.000646039,0.0001221678],"domain_scores_gemma":[0.9995315,0.0001816741,0.00007431471,0.00005593862,0.0001061735,0.00005043446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002552014,0.00003886324,0.0004284681,0.00005622835,0.00002676822,0.00003041997,0.000009718569,0.0002801539,0.9915279,0.0001787436,0.0001440256,0.007253114],"study_design_scores_gemma":[0.0000117141,0.0001308354,0.002405828,0.00000610885,0.00002659989,0.0002154337,0.00001988125,0.009486181,0.9838186,0.0002889117,0.003574121,0.00001573237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4141204,0.004684145,0.572892,0.0005083156,0.0001009249,0.0004558517,0.001031409,0.002188823,0.004018054],"genre_scores_gemma":[0.5394475,0.005372997,0.4469271,0.000585952,0.00006593218,0.0006789611,0.0020903,0.0002676245,0.004563665],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001151324,"threshold_uncertainty_score":0.006088853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03481642779193234,"score_gpt":0.3204959817440632,"score_spread":0.2856795539521309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}