{"id":"W1978867062","doi":"10.1016/j.cell.2012.11.014","title":"Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":271,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; National Eye Institute; Intellectual and Developmental Disabilities Research Center; Biological and Environmental Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ontario Genomics Institute; Wellcome Trust; National Institutes of Health; Ontario Genomics; Genome Canada; Ontario Innovation Trust; University of Chicago; Pfizer; Fudan University; Argonne National Laboratory; U.S. Department of Energy; Brigham and Women's Hospital; Eli Lilly and Company","keywords":"Biology; DNA methylation; Regulation of gene expression; Gene; Xenopus; Promoter; Transcription factor; Cell biology; Epigenetics; Genetics; Regulator; DNA demethylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001224921,0.0002894764,0.0002446822,0.0002214989,0.0002737856,0.0004327365,0.0002867196,0.0002304109,0.003081642],"category_scores_gemma":[0.0001532492,0.0002384773,0.0002400322,0.0001562335,0.0003047893,0.0003462006,0.0005619983,0.000461899,0.0005388843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006749694,"about_ca_system_score_gemma":0.0003008113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001569375,"about_ca_topic_score_gemma":0.006301175,"domain_scores_codex":[0.9998287,0.00001658365,0.00001057686,0.00004099314,0.00004424496,0.00005884026],"domain_scores_gemma":[0.9998425,0.00003400323,0.00003628822,0.00002093466,0.00002182398,0.00004452036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005781745,0.000005651214,0.0002515531,0.00001184942,0.000001964473,0.00003957545,0.000008540512,0.00002054056,0.9983315,0.000354948,0.00004794826,0.0008681329],"study_design_scores_gemma":[0.000009972303,0.00003436361,0.01177666,0.00000266729,0.000007096952,0.0001399795,0.00003036646,0.0007544627,0.9850678,0.0001119805,0.002060763,0.000003950437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783443,0.003823325,0.009373939,0.0002909706,0.0001084861,0.00003115135,0.0004368596,0.0002253063,0.007365639],"genre_scores_gemma":[0.9840167,0.0005427933,0.002481803,0.0001082917,0.00001930686,0.00003102197,0.0004838429,0.00007074976,0.01224549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003081642,"threshold_uncertainty_score":0.01030916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361635737473288,"score_gpt":0.2514054169463891,"score_spread":0.2377890595716562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}