{"id":"W1978867062","doi":"10.1016/j.cell.2012.11.014","title":"Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":271,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; National Eye Institute; Intellectual and Developmental Disabilities Research Center; Biological and Environmental Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ontario Genomics Institute; Wellcome Trust; National Institutes of Health; Ontario Genomics; Genome Canada; Ontario Innovation Trust; University of Chicago; Pfizer; Fudan University; Argonne National Laboratory; U.S. Department of Energy; Brigham and Women's Hospital; Eli Lilly and Company","keywords":"Biology; DNA methylation; Regulation of gene expression; Gene; Xenopus; Promoter; Transcription factor; Cell biology; Epigenetics; Genetics; Regulator; DNA demethylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756624,0.0001170144,0.00009561831,0.00001714566,0.0001196808,0.00002300619,0.00003689217,0.00008679841,0.000002573182],"category_scores_gemma":[0.00001443917,0.0001046204,0.00001992879,0.00002184804,0.00003829979,0.00000592149,0.00006464453,0.00003071019,9.023069e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006820632,"about_ca_system_score_gemma":0.00002362516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003105682,"about_ca_topic_score_gemma":0.00000805668,"domain_scores_codex":[0.9994155,0.00003774856,0.00009798609,0.0002013665,0.00004772114,0.0001997425],"domain_scores_gemma":[0.999687,0.00001248881,0.00004523399,0.0001086418,0.0000401921,0.0001064423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004609261,0.00003774437,0.004837843,0.00002656049,0.00001164368,2.466751e-7,0.000183557,0.00001001468,0.9863386,0.00001079749,0.00002615272,0.008470756],"study_design_scores_gemma":[0.0004467564,0.00009719903,0.02203759,0.000002238345,0.000007569496,9.385915e-7,0.00002414944,0.000100897,0.9388987,0.00002839929,0.03820745,0.0001481154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888178,0.007131763,0.003533195,0.00004747995,0.00008627449,0.0002140607,0.00001221587,0.000004964319,0.0001523069],"genre_scores_gemma":[0.9929539,0.0003171004,0.005709229,0.00003370553,0.0001335536,0.00002383604,0.00004037163,0.00001511748,0.0007732154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0474399,"threshold_uncertainty_score":0.4266298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361635737473288,"score_gpt":0.2514054169463891,"score_spread":0.2377890595716562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}