{"id":"W1978907515","doi":"10.1038/npp.2012.91","title":"Chronic Δ9-Tetrahydrocannabinol Exposure Induces a Sensitization of Dopamine D2/3 Receptors in the Mesoaccumbens and Nigrostriatal Systems","year":2012,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Centre for Addiction and Mental Health; AstraZeneca; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Quinpirole; Dopamine receptor D2; Nucleus accumbens; Chemistry; Mesolimbic pathway; Dopamine; Internal medicine; Endocrinology; Agonist; Pharmacology; Cannabinoid; Dopamine receptor D3; Raclopride; Receptor; Dopaminergic; Medicine; Ventral tegmental area","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000605798,0.0001854926,0.0003592262,0.0002909465,0.00006553168,0.00001832639,0.0001352143,0.0001469301,0.0001180396],"category_scores_gemma":[0.0001123661,0.0001359054,0.00006309955,0.0006315744,0.000201675,0.00009107112,0.00005144786,0.0005023651,0.00001043954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007659201,"about_ca_system_score_gemma":0.0001284541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001228308,"about_ca_topic_score_gemma":0.00001648727,"domain_scores_codex":[0.9979883,0.0004439857,0.0004245873,0.0002841223,0.000354934,0.0005040522],"domain_scores_gemma":[0.9992495,0.0000710031,0.0001379548,0.0002580867,0.0001088087,0.0001746299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001006511,0.0008158552,0.09877352,0.000822314,0.0001265198,0.000120961,0.00249964,0.0001186435,0.8251441,0.0002183009,0.05055226,0.01980144],"study_design_scores_gemma":[0.01799974,0.005302736,0.7769131,0.000208258,0.0003983876,0.002958972,0.002004864,0.001266128,0.02680232,0.00001224345,0.1654623,0.0006710075],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865134,0.004697936,0.000005672265,0.005981966,0.00119711,0.0009453131,0.00001012269,0.0000218378,0.0006266453],"genre_scores_gemma":[0.9966836,0.0005250447,0.000003796394,0.0004302775,0.001010782,0.00009684324,0.00001584453,0.00003057273,0.001203255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7983418,"threshold_uncertainty_score":0.5542062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02011013441109612,"score_gpt":0.3151651785996553,"score_spread":0.2950550441885592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}