{"id":"W1978921288","doi":"10.1021/jm901771h","title":"The Discovery of 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic Acid (MK-2894), A Potent and Selective Prostaglandin E<sub>2</sub>Subtype 4 Receptor Antagonist","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Trifluoromethyl; Antagonist; Benzoic acid; Prostaglandin; Pharmacokinetics; Pharmacology; Prostaglandin E2; Tolerability; Stereochemistry; Internal medicine; Biochemistry; Receptor; Adverse effect; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001294985,0.0002673841,0.0003781019,0.000263081,0.0001117084,0.00021857,0.000391579,0.0004037771,0.001761212],"category_scores_gemma":[0.0001793022,0.0001464613,0.0001840023,0.0001220882,0.0002736541,0.0001946939,0.0002623856,0.0005098476,0.0008783821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003328384,"about_ca_system_score_gemma":0.0004045698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004999349,"about_ca_topic_score_gemma":0.0007167807,"domain_scores_codex":[0.9999361,0.00001195292,0.000003635277,0.0000123216,0.000017626,0.00001835998],"domain_scores_gemma":[0.9999566,0.000004970288,0.00001310147,0.000003014267,0.00001107661,0.00001119766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004509448,0.0001201146,0.0002869758,0.0003654576,0.00002791165,0.0006427747,0.00002691948,0.0009781923,0.9589221,0.002583215,0.000808776,0.03478668],"study_design_scores_gemma":[0.0004591207,0.004540008,0.003989792,0.00003836803,0.0001020579,0.002457612,0.00003562874,0.003108629,0.9337996,0.001014812,0.05041677,0.00003768421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8787601,0.04488032,0.05043099,0.002108033,0.0007315478,0.0005434256,0.001370409,0.0004288114,0.02074634],"genre_scores_gemma":[0.9564468,0.01842228,0.01190683,0.0004398244,0.0001756333,0.0001249286,0.0006446131,0.00002208418,0.01181708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001761212,"threshold_uncertainty_score":0.0058918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004413155386921139,"score_gpt":0.2261846997431698,"score_spread":0.2217715443562487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}