{"id":"W1978932179","doi":"10.1038/sj.cdd.4401432","title":"Multiple mechanisms promote the inhibition of classical nuclear import upon exposure to severe oxidative stress","year":2004,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Nuclear transport; Importin; Ran; Cell biology; Chemistry; Oxidative stress; Nuclear pore; Nuclear localization sequence; Nucleoporin; Cytoplasm; Cell nucleus; Biophysics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006258267,0.0009654077,0.00102947,0.0005122015,0.000450004,0.0009705705,0.0006639223,0.0006366483,0.00153481],"category_scores_gemma":[0.0004195957,0.0004071399,0.0008067241,0.0002918332,0.0009917388,0.001205342,0.001122078,0.001335299,0.0004115112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008352327,"about_ca_system_score_gemma":0.0005856574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000554333,"about_ca_topic_score_gemma":0.0009790045,"domain_scores_codex":[0.9995636,0.00004182642,0.00005729913,0.00008295781,0.0001268115,0.0001274553],"domain_scores_gemma":[0.9991664,0.0001139815,0.0002291708,0.000165991,0.0001475329,0.0001769865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002480983,0.00002850893,0.0003151007,0.00008312132,0.00001474619,0.0001064234,0.00002904922,0.00005144191,0.9975263,0.0004001729,0.00002671771,0.001170318],"study_design_scores_gemma":[0.00002582589,0.0001752134,0.01037803,0.0000166982,0.00002283498,0.0003298619,0.00007426392,0.0004359283,0.9870175,0.0002596249,0.001251434,0.00001290401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959615,0.01018916,0.02396666,0.0006347595,0.0001791381,0.0001845174,0.0004259153,0.0006372603,0.004167584],"genre_scores_gemma":[0.9900379,0.002313649,0.00438793,0.0001041069,0.00004442399,0.00006841786,0.0003648862,0.00004899453,0.002629699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00153481,"threshold_uncertainty_score":0.006060123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005418441071750214,"score_gpt":0.1913377569185602,"score_spread":0.18591931584681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}