{"id":"W1979016562","doi":"10.1038/srep07677","title":"A conserved P-loop anchor limits the structural dynamics that mediate nucleotide dissociation in EF-Tu","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Western Canada Research Grid; Compute Canada","keywords":"Molecular dynamics; Nucleotide; GTPase; GTP'; In silico; Conserved sequence; Amino acid; Stem-loop; EF-Tu; Protein structure; Biophysics; Chemistry; Biology; Peptide sequence; RNA; Biochemistry; Transfer RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289944,0.0002083244,0.0002211392,0.0001348701,0.0002324458,0.0002963134,0.000283011,0.0002713274,0.000585324],"category_scores_gemma":[0.0004846264,0.000168529,0.000151828,0.0001245537,0.0004279283,0.000349319,0.0002460716,0.0003266986,0.0001404172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236525,"about_ca_system_score_gemma":0.0002131498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005579335,"about_ca_topic_score_gemma":0.000621772,"domain_scores_codex":[0.9999316,0.000009229038,0.000004662971,0.00002103172,0.00001994229,0.00001365737],"domain_scores_gemma":[0.9998129,0.00006780087,0.00005785225,0.00001527946,0.00001002067,0.00003627067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002432028,0.00004224784,0.001970064,0.00003115921,0.00001237819,0.0001702958,0.00003513603,0.003608148,0.9894751,0.0006316321,0.00002806455,0.003752493],"study_design_scores_gemma":[0.00009571326,0.0006998702,0.0293511,0.00002548728,0.00005765764,0.0008761896,0.00008671565,0.06934291,0.8959725,0.001860401,0.001588355,0.00004302359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979569,0.00009632879,0.00172603,0.00001292982,0.000002141309,0.000002066572,0.00001290758,0.0000295052,0.000161247],"genre_scores_gemma":[0.9994602,0.00002488624,0.0004257406,0.000003791987,9.880532e-7,0.000001643733,0.0000218547,0.000004705532,0.00005618548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000585324,"threshold_uncertainty_score":0.001958072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02353955420406128,"score_gpt":0.2534062113909971,"score_spread":0.2298666571869358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}