{"id":"W1979022543","doi":"10.1111/j.0906-6705.2004.00183.x","title":"Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early‐onset, psoriasis‐like skin pathology: Expression of amphiregulin in the basal epidermis is also associated with synovitis","year":2004,"lang":"en","type":"article","venue":"Experimental Dermatology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cascades (Canada)","funders":"","keywords":"Acanthosis; Psoriasis; Involucrin; Pathology; Epidermis (zoology); Amphiregulin; Biology; Genetically modified mouse; Keratin 5; Transgene; Keratinocyte; Immunohistochemistry; Medicine; Immunology; Hyperkeratosis; Anatomy; Epidermal growth factor receptor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458401,0.0004221047,0.0001907466,0.0003855461,0.0001451486,0.0003043332,0.0001530994,0.000360768,0.001018875],"category_scores_gemma":[0.00008570633,0.0002357972,0.0002958115,0.0001208788,0.0002496906,0.0001862291,0.0002424773,0.000784906,0.0004968861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001561483,"about_ca_system_score_gemma":0.000122725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001905574,"about_ca_topic_score_gemma":0.0003577481,"domain_scores_codex":[0.9997632,0.00003431694,0.00003199963,0.00006256249,0.00006457406,0.00004342758],"domain_scores_gemma":[0.9998409,0.00001787133,0.00005790906,0.00002456649,0.00000930002,0.00004944102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003796495,0.00001831209,0.0001108307,0.000007211153,0.000001878696,0.0000627832,0.000006012132,0.00001107594,0.9994816,0.00002154722,0.000005430509,0.0002353249],"study_design_scores_gemma":[0.00003822556,0.000567511,0.01427343,0.00001114664,0.0000262639,0.001978809,0.00005152433,0.0007266979,0.9809151,0.00007559752,0.00132873,0.000007039683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960014,0.0004367561,0.002130056,0.00003476785,0.00001189659,0.00003498701,0.0002535314,0.0001002585,0.0009964294],"genre_scores_gemma":[0.9949144,0.0003464015,0.002005866,0.00003844379,0.000006694802,0.00003773529,0.0004289389,0.00002833205,0.002193236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018875,"threshold_uncertainty_score":0.003408492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02698600178607725,"score_gpt":0.3206920696480167,"score_spread":0.2937060678619395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}