{"id":"W1979022543","doi":"10.1111/j.0906-6705.2004.00183.x","title":"Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early‐onset, psoriasis‐like skin pathology: Expression of amphiregulin in the basal epidermis is also associated with synovitis","year":2004,"lang":"en","type":"article","venue":"Experimental Dermatology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cascades (Canada)","funders":"","keywords":"Acanthosis; Psoriasis; Involucrin; Pathology; Epidermis (zoology); Amphiregulin; Biology; Genetically modified mouse; Keratin 5; Transgene; Keratinocyte; Immunohistochemistry; Medicine; Immunology; Hyperkeratosis; Anatomy; Epidermal growth factor receptor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006514118,0.0003814026,0.001112038,0.0003605196,0.00013118,0.000009362769,0.0005828555,0.0003746508,0.0001513499],"category_scores_gemma":[0.0001001677,0.0002324168,0.0002510061,0.0005919039,0.0009817643,0.0001471228,0.0001192596,0.0005878193,0.000004524205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007416934,"about_ca_system_score_gemma":0.0001800713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001677262,"about_ca_topic_score_gemma":0.0003515414,"domain_scores_codex":[0.9956797,0.00126662,0.001160244,0.0005007835,0.0007974311,0.0005951881],"domain_scores_gemma":[0.9980347,0.0008103477,0.000456742,0.0004973495,0.0001008624,0.00009996174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002050489,0.00294061,0.0540264,0.0001930569,0.0001148159,0.0006988009,0.04076168,0.00001088043,0.8976973,0.0002316445,0.00110044,0.0001738788],"study_design_scores_gemma":[0.005158619,0.0009085868,0.1602248,0.0007010311,0.00004742805,0.0009386419,0.00667082,0.000007086386,0.8247826,0.0003164689,0.00004061205,0.0002033476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994801,0.001521063,0.000006806551,0.00224714,0.00007940101,0.0009073941,0.0001077632,0.00001433418,0.0003150747],"genre_scores_gemma":[0.9985331,0.0001082982,0.0002650919,0.0007158236,0.00004115516,0.0001418541,0.0001118892,0.00003455873,0.00004818716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1061984,"threshold_uncertainty_score":0.9477682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02698600178607725,"score_gpt":0.3206920696480167,"score_spread":0.2937060678619395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}